Neuroscience 2002 Abstract
| Presentation Number: | 853.1 |
|---|---|
| Abstract Title: | <b>CHANGES IN 5HT<sub>7</sub> RECEPTOR DISTRIBUTION IN CAT SPINAL CORD FOLLOWING CHRONIC TRANSECTION.</b> |
| Authors: |
Noga, B. R.*1
; Johnson, D. M. G.1
; Pinzon, A.1
; Riesgo, M.1
; Basile, M.2
; Mash, D. C.2
1Miami Proj To Cure Paralysis, Univ Miami Sch Med, Miami, FL 2Department of Neurology, Univ Miami Sch Med, Miami, FL |
| Primary Theme and Topics |
Motor Systems - Spinal Cord |
| Session: |
853. Spinal cord: spinal cord injury Poster |
| Presentation Time: | Thursday, November 7, 2002 8:00 AM-9:00 AM |
| Location: | Hall A2-B3 F-72 |
| Keywords: | serotonin receptor, autoradiography, spinal cord injury |
Serotonin is a powerful neuromodulator of locomotor activity in the mammalian spinal cord. We have recently shown that locomotor-activated neurons are innervated by serotoninergic fibers and that a significant percentage of them possess 5HT7 receptors on their soma and proximal dendrites (Johnson et al. SFN Abstr. 2002). Since serotonergic denervation of these cells after spinal cord injury (SCI) will likely further compromise locomotor function, serotonin could possibly be used in transmitter replacement therapies to reverse these effects. We, therefore, examined the effect of chronic SCI by spinal transection on the pattern and distribution of these receptors to determine whether there are any long-term changes. The spinal cords of 9 cats were transected at the T8/9 level and the animals allowed to survive for 1, 3 and 6 months. Their lumbar spinal cords were processed for quantitative receptor autoradiography using an antibody directed against the receptor. Spinal cords were compared to control animals. Preliminary results show: 1) a variable laminar distribution across the lumbar segments with receptor densities greatest in the dorsal horn (laminae I-III); 2) a significant increase in receptor density in lamina VII, 3 months post-injury; and 3) a return to normal values in animals spinalized for 6 months. The fact that the distribution of 5HT7 receptors appears to be normalized in areas containing locomotor-activated neurons, 6 months following injury, despite denervation, is promising for future transmitter replacement interventions targeting serotonergic receptors in the chronic stages of SCI.
Supported by Miami Project and the State of Florida
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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