Neuroscience 2005 Abstract
| Presentation Number: | 769.1 |
|---|---|
| Abstract Title: | Neurodynamically defined memory systems from simultaneous fMRI and EEG measures. |
| Authors: |
Haist, F.*1
; Jung, T.2
; Duann, J.2
; Adamo, M.3
; Vankov, A.2
; Makeig, S.2
1Dept. Psychiatry, UC San Diego, La Jolla, CA 2Swartz Center for Comp. Neurosci., UC San Diego, La Jolla, CA 3ON, UCSD Resch Aging & Dev Lab 500 Gilman Drive, 0959, 92093-0959, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Learning and long-term memory |
| Secondary Theme and Topics | Techniques in Neuroscience<br />- Data Analysis and Statistics |
| Session: |
769. Long-Term Memory III Poster |
| Presentation Time: | Tuesday, November 15, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # MM25 |
| Keywords: | cognition, imaging, electrophysiology |
Human memory depends on coordinated activity across discrete brain regions organized into information-processing systems. Yet, defining the organization of brain memory systems from regional activations obtained in functional imaging studies remains a challenge. Here, we describe a method for defining memory systems from functional magnetic resonance imaging (FMRI) and 71-channel electroencephalographic (EEG) data recorded simultaneously. Six healthy young adults participated in a verbal paired-associate test. Each studied 72 pairs of highly associated words (flower-rose) and 72 low associate pairs (army-table) prior to scanning. During testing, subjects were shown the first word of the pair for 1500 ms and encouraged to recollect the associated word. A second word was then shown and subjects made a yes/no decision as to whether it completed the studied pair. Subjects obtained a mean of 82% correct recognition. Traditional parametric analyses of the FMRI data identified several regions of activity, including a large region in the left prefrontal cortex (L-PFC). We demonstrate that independent components analysis (ICA) was able to identify two components capturing the activity in the L-PFC. A group analysis of these components revealed that activity in the left inferior frontal gyrus (BA 45; Broca’s area) was linked to activity in left superior temporal gyrus (BA 22; Wernicke’s area), revealing a language-related co-activation in paired-associate recollection. Activity in left middle frontal gyrus (BA 9) was co-activated with a region in right middle frontal gyrus. These findings, merged with measures of temporal and spectral EEG modulations/perturbations can provide a convergent test for systems defined by BOLD ICA, and a more complete multi-resolution 4-D (space+time) description of memory task-related activities. The technical challenges of simultaneous EEG/FMRI acquisition will be discussed.
Supported by NIA P50-AG05131
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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