Neuroscience 2003 Abstract
| Presentation Number: | 735.6 |
|---|---|
| Abstract Title: | Age-related human brain volume changes: an MRI volumetric study. |
| Authors: |
Shan, Z.*1,3
; Liu, J.1
; Sahgal, V.2
; Yue, G. H.1,2,3
1Biomed. Engin., Cleveland Clin. Fndn., Cleveland, OH 2Physical Med. and Rehab., Cleveland Clin. Fndn., Cleveland, OH 3OH, 9500 Euclid Ave, 44114, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Aging -- Physiology |
| Session: |
735. Aging: Physiology Poster |
| Presentation Time: | Tuesday, November 11, 2003 2:00 PM-3:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # Z8 |
| Keywords: | AGING, MRI, BRAIN, VOLUMETRICS |
Although age-related brain volume changes have widely been reported, many questions are yet to be answered. For example, normative data of the brain volume and results of gender and side (left-right) brain volume asymmetry in aging are largely unavailable. In this study, we measured age-related brain volume changes with an automated method. Three-dimensional magnetic resonance images (MRI) of young and old volunteers were collected. The MRI data were quantitatively analyzed by a recently developed automated method. Effects of age, gender, and side on absolute and relative volume measurements of the brain structures were statistically evaluated. Compared to the young group, the elderly subjects showed a 15% volume loss in the whole brain and hemispheres, and a 22% volume loss in the frontal lobes. The coefficient of variation (CV) of the whole brain, hemisphere, and frontal lobe volume measurements were significantly smaller in the old group than in the young group. The relative volume of the left hemisphere in the older group decreased more than that of the right hemisphere. Men had larger left-right asymmetry than women. The Older males showed a more significant left hemisphere volume loss than older females and a similar trend was observed for the volume of the left frontal lobe. Thus, significant brain volume losses occur as people grow older. This age-related brain atrophy is more pronounced in the frontal lobes than in the whole brain or hemispheres. Older males show more severe asymmetrical atrophy in the left hemisphere and frontal lobe than older females, which may reflect age- and gender-related functional deterioration in these cortical regions. The reduction in coefficient of variation in aged brain volume suggests that the brain tends to evolve to a similar size when people grow older.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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