Neuroscience 2002 Abstract
| Presentation Number: | 809.4 |
|---|---|
| Abstract Title: | Combined Serotonergic-Potentiation and MAO-A Inhibition by Paramethoxyamphetamine (PMA) and Paramethoxymethamphetamine (PMMA): Implications for Ecstasy Fatalities. |
| Authors: |
Pablo, J. P.*1
; Izenwasser, S.1
; Efange, S.2
; Ouyang, Q.1
; Shen, S.1
; Hearn, W. L.3
; Mash, D. C.1
1Dept Neurol, Univ Miami Sch Med, Miami, FL 2Dept Radiology, Univ. Minnesota, Minneapolis, MN 3Toxicology Div., Miami-Dade County Medical Examiner Dept., Miami, FL |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Amphetamines |
| Session: |
809. Addiction and drugs of abuse: amphetamines V Poster |
| Presentation Time: | Wednesday, November 6, 2002 4:00 PM-5:00 PM |
| Location: | Hall A2-B3 Z-82 |
| Keywords: | Serotonin Syndrome, MAO Inhibitor, Amphetamine |
The ingestion of PMA, a ring-substituted amphetamine derivative contained in the small white tablets inscribed with the characteristic Club Drug Mitsubishi 3-Diamond logo has led to deaths following recreational use. Most of the tablets sold with this logo contain the entactogen 3, 4-methylenedioxymethamphetamine (MDMA, Ecstasy). Paramethoxymethamphetamine (PMMA) has also been identified in Ecstasy tablets. We have compared the activities of PMA and PMMA to MDMA and other sympathoamines in radioligand binding, and uptake assays targeted to the DAT and serotonin transporter, as well as DA-release assays. The results demonstrate that PMA and PMMA were equipotent to MDMA in serotonin transporter binding and DA-release assays. In contrast, PMA was approximately 4.6 and 9.4-fold less active than MDMA at inhibiting radioligand binding to dopamine transporter (DAT) and stimulating dopamine release, respectively. PMMA also was less potent than MDMA at the DAT. Neither PMA nor PMMA inhibited MAO-B activity. However, PMA (30-fold) and PMMA (7-fold) were more potent than MDMA at inhibiting MAO-A activity. The combined serotonin-potentiating and MAO-A inhibiting activity of PMA and PMMA may account for the potentially dangerous and fatal effects of these sympathoamines.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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