Neuroscience 2002 Abstract
| Presentation Number: | 76.8 |
|---|---|
| Abstract Title: | FAT DEPRIVATION-INDUCED HYPERPHAGIA REVEALS POTENTIAL VAGAL INTESTINAL AFFERENT ROLE IN LONG-TERM FEEDING CONTROLS. |
| Authors: |
Byerly, M. S.*1
; Fox, E. A.1
1Dept Neurosci, Purdue Univ, W. Lafayette, IN |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Regulation of Food Intake and Body Weight |
| Session: |
76. Regulation of food intake and body weight: brain-gut interactions Poster |
| Presentation Time: | Sunday, November 3, 2002 11:00 AM-12:00 PM |
| Location: | Hall A2-B3 P-5 |
| Keywords: | intraganglionic laminar endings, neurotrophin-4, small intestine, macronutrient |
We recently reported neurotrophin-4 (NT-4) knockout mice lacking 90% of vagal afferents innervating the smooth muscle of the small intestine (intraganglionic laminar endings, IGLEs) and this loss is associated with deficits in short-term satiety (intake associated with a single meal), whereas long-term feeding controls (intake integrated across several meals) appeared intact (Fox et al., J.Neurosci,21,8602,2001). However, since nutritionally balanced diets were used in this study, it is possible that the missing vagal afferents might play a role in long-term regulation under more challenging conditions. To examine this, we subjected NT-4 mutants and wild types to a diet regime of intermittent hi-fat exposure that produces dramatic hyperphagia relative to continuous hi-fat exposure (Byerly & Fox, 2001 SFN mtg). NT-4 mutants and wild types (n=26) received either (1) continuous access to a 43% fat source ad libitum or (2) alternating access to the 43% fat source on even-numbered days and powdered chow on odd-numbered days. On hi-fat exposure days, wild type mice with intermittent hi-fat exposure consumed 25% more calories/day than continuous access groups (p< 0.05). Interestingly, NT-4 mutants with intermittent hi-fat consumed 31% more calories/day relative to continuous access groups (p< 0.05). Moreover, this excess hyperphagia in NT-4 mutants vs. wild types having intermittent hi-fat exposure was significant (10%; p< 0.05). These results suggest that vagal small intestinal afferents missing in NT-4 mutants may contribute to the long-term regulation of food intake, especially when the regulatory system is challenged.
Supported by School of Liberal Arts Grant, Purdue University
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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