Neuroscience 2001 Abstract
| Presentation Number: | 781.6 |
|---|---|
| Abstract Title: | Galanin blocks memory consolidation: evidence supporting inhibition of adenylate cyclase activation. |
| Authors: |
Kinney, J. W.*1
; Starosta, G.1
; Crawley, J. N.1
1Sec Behav Neuropharmacol, NIMH, Bethesda, MD |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning & memory: Pharmacology |
| Secondary Theme and Topics | Cognition and Behavior<br />- Behavioral Pharmacology<br />-- Neuropeptides and behavior |
| Session: |
781. Animal cognition and behavior: learning and memory--pharmacology VII Slide |
| Presentation Time: | Wednesday, November 14, 2001 2:15 PM-2:30 PM |
| Location: | Room 2 |
| Keywords: | learning, forskolin, Morris water task, Alzheimers |
Galanin is a 29 amino acid neuropeptide that inhibits the release of glutamate and acetylcholine, and produces performance deficits in a variety of learning and memory tasks (reviewed in Wrenn and Crawley, 2001). Our previous studies revealed that central administration of galanin after subjects had completed daily training trials in the Morris water task interfered with distal cue learning of the platform location (SFN abstract 653.12,2000). We propose a novel mechanism by which galanin interferes with memory consolidation based on the overlap of the signal transduction pathway of galanin (see Iismaa and Shine, 1999) and the downstream molecular events required for consolidation. Our hypothesis is that galanin interferes with adenylate cyclase activation, thus decreasing the cAMP dependent protein kinase A cascade. To test this model, forskolin was centrally administered in combination with galanin to Sprague-Dawley rats in the Morris hidden platform task. Di-deoxyforskolin was similarly administered as an inactive control.
Forskolin, but not di-deoxyforskolin, rescued the deficits in distal cue learning produced by galanin in the Morris water task. These results support the hypothesis that galanin interferes with consolidation processes by inhibiting adenylate cyclase activity, leading to inhibition of downstream molecular events that are necessary for consolidation of long-term memory.
Forskolin, but not di-deoxyforskolin, rescued the deficits in distal cue learning produced by galanin in the Morris water task. These results support the hypothesis that galanin interferes with consolidation processes by inhibiting adenylate cyclase activity, leading to inhibition of downstream molecular events that are necessary for consolidation of long-term memory.
Supported by the NIMH IRP
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
