Neuroscience 2001 Abstract
| Presentation Number: | 780.5 |
|---|---|
| Abstract Title: | DIFFERENTIAL RATE OF CHANGE IN CALLOSAL AND VENTRICULAR SIZE: A 4-YEAR LONGITUDINAL MRI STUDY. |
| Authors: |
Sullivan, E. V.*1
; Pfefferbaum, A.2
; Adalsteinsson, E.3
; Swan, G. E.2
; Carmelli, D.2
1Psychiatry, Stanford Univ, Stanford, CA 2SRI International, Menlo Park, CA 3Radiology, Stanford Univ, Stanford, CA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Aging -- Other |
| Session: |
780. Aging: molecular and physiological studies Slide |
| Presentation Time: | Wednesday, November 14, 2001 2:00 PM-2:15 PM |
| Location: | Room 1B |
| Keywords: | aging, brain imaging, corpus callosum, lateral ventricle |
Brain structure size changes with normal aging, but the rate at which different structures change is controversial, likely owing to inferences based on cross-sectional study. We used MRI performed twice, 4 years apart, to compare rate of age-related size change of the corpus callosum, which has been inconsistently observed to thin with age, with change in the lateral ventricles, which incontrovertibly enlarge. Subjects were 215 community dwelling, elderly men (70-82 yr), participants in the NHLBI longitudinal study of cardiovascular risk factors. Contiguous sagittal and coronal images were acquired and realigned to the anterior commissure. A midsagittal image was extracted for semi-automated callosal edge identification; 3 coronal slices were extracted for ventricular outlining. MRIs were processed together and scored blind to subject identity. Percent change in size was significant for callosal and ventricular measures but rate of annual ventricular expansion (2.9%) was significantly greater than rate of callosal shrinkage (-0.9%). Callosal regions showed equivalent annual rates of shrinkage (genu=-0.9%; body=-0.7%; splenium=-1.0%); ventricular dilatation was symmetrical (left=2.8%; right=2.9%). Neither callosal and ventricular change rates correlated (r=.01) nor did genu and splenium change rates correlate (r=.05). Thus differential rates of change can occur in different brain regions in aging, and change rate in one region may be independent of change rate in other regions, even within a brain structure.
Supported by HL51429,AG19717,AA12388,AA10723
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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