Neuroscience 2005 Abstract
| Presentation Number: | 723.20 |
|---|---|
| Abstract Title: | Pathway specific modulation by nicotine. |
| Authors: |
Takesian, A. E.*1
; Fujisawa, S.1
; Mahadomrongkul, V.1
; Aoki, C.1
1Center for Neural Science, New York Univ., New York, NY |
| Primary Theme and Topics |
Neural Excitability, Synapses, and Glia: Cellular Mechanisms - Ligand-Gated Ion Channels -- Nicotinic acelylcholine receptors: Localization |
| Session: |
723. Nicotinic Acetylcholine Receptors: Localization Poster |
| Presentation Time: | Tuesday, November 15, 2005 4:00 PM-5:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # E46 |
| Keywords: | ACETYLCHOLINE RECEPTOR, NICOTINIC RECEPTOR, BETA, ELECTRON MICROSCOPY |
The ability of acetylcholine to shift cortical flow of activity between the thalamo-cortical (TC) and cortico-cortical (CC) pathways has been the basis for models implicating the role of acetylcholine in attention. However, no conclusive mechanism has been provided for this shift and anatomical data linked to this theory is scarce. Nicotinic receptors have been associated with pre-synaptic enhancement of neurotransmitter release within the brain, yet our recent physiological data suggest that nicotine also acts by a pre-synaptic mechanism to lower synaptic efficacy (Levy et al., SfN 2004). The polar nicotine effects likely depend upon the relative densities and locations of the nicotinic receptor subtypes. Thus, we are performing dual labeling of the β2 subunit of nicotinic receptors and the layer V pyramidal neurons to localize the sites of nicotinic modulation on these cells across the cortical lamina. Using EM, we are looking for the presence of β2 on pre- and post-synaptic membranes of thalamo-cortical (layer IV) and cortico-cortical synapses (layer I,V). Our findings so far localize β2 subunits to predominantly extra-synaptic regions on both pre- and post-synaptic membranes of cortical layers dominated by TC and by CC synapses.
Supported by EY13145, NS41091, P30 EY13079
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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