Neuroscience 2005 Abstract
| Presentation Number: | 719.14 |
|---|---|
| Abstract Title: | Inflammatory cytokine expression in injured mouse brain. |
| Authors: |
Ikeshima-Kataoka, H.*1
; Shen, J.2
; Natake, Y.1
; Saito, S.1
; Yuasa, S.3
1Dept Mol Immunol, Inst DNA Med, Jikei Univ. School of Medicine, Tokyo, Japan 2Japan, 3-25-8 Nishi-Shinbashi, Minato-ku, 105-8461, 3Dept Gene Ther, Inst DNA Med, 3-25-8 Nishi-Shinbashi, Minato-ku, 105-8461, |
| Primary Theme and Topics |
Development - Transplantation and Regeneration -- Regeneration: CNS |
| Secondary Theme and Topics | Homeostatic and Neuroendocrine Systems<br />- Neuroendocrine<br />-- Neuroendocrine regulation: Other |
| Session: |
719. Regeneration: CNS III Poster |
| Presentation Time: | Tuesday, November 15, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # D30 |
| Keywords: | tenascin, astrocytes, inflammatory cytokine, brain lesion |
Tenascin (TN) is one of the astroglia-derived extracellular matrix proteins, expressed in radial glia and immature astroglia in the developing mouse brain. TN can be detected only very low levels in adult mouse brain, however, is highly up-regulated in sites of injured central nervous system (CNS) depending on the proliferation of reactive astrocytes with GFAP expression. To investigate the role of tenascin-expressing astrocytes played in the injured brain, we analyzed TN knockout (TN/KO) mouse. We have previously reported that TN is one of the essential molecules for proliferation of the primary culture of astrocytes, and from our injured mouse brain model with stab wound, GFAP expression in the lesion sites was down regulated sharply at earlier stage of after the lesion in TN/KO mouse than the WT mouse (SFN 2004). Some of the inflammatory cytokines are expressed not only in lymphocytes but also in injured spinal cord, and also those receptors are expressed in cultured astrocytes. To evaluate immune responses in CNS, inflammatory cytokine expression was determined in injured mouse brain model compared with TN/KO and WT mouse. From our data of quantitative RT-PCR method, tenascin had the possible roles for some of the cytokine expression in the CNS lesion sites. We are currently examining the relationship between tenascin and the cytokine expression.
Supported by Japan Society for the Promotion of Science (JSPS)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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