Neuroscience 2004 Abstract
| Presentation Number: | 694.18 |
|---|---|
| Abstract Title: | Reproducible objective quantification scheme (ROQS) for MRI assessment of white matter tract integrity: Applications to mild traumatic brain injury (TBI). |
| Authors: |
Niogi, S. N.*1
; Mukherjee, P.2
; Ghajar, J.1,3
; Zimmerman, R.1
; Shannon, K. E.
; Shupenko, L. A.
; McCandliss, B.1
; Cognitive and Neurobiological Research Consortium in Traumatic Brain Injury3
1Weill Cornell Med. Col., New York, NY 2CA, 1300 York Ave, 10021, 3USA, 1300 York Ave, 10021, |
| Primary Theme and Topics |
Techniques in Neuroscience - Data analysis, physiological methods, statistics |
| Session: |
694. Techniques: Brain Imaging Methods II Poster |
| Presentation Time: | Tuesday, October 26, 2004 9:00 AM-10:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # FFF32 |
| Keywords: | BRAIN IMAGING, TBI, DTI |
Over 1.5 million cases of TBI are reported annually in the U.S., yet reliable tools for prognosis of persistent symptoms following mild TBI are elusive. Diffuse Axonal Injury (DAI) is the most common form of damage, yet current MRI techniques cannot quantify DAI, limiting prognosis and treatment. We present a method to quantitatively evaluate the integrity of white matter tracks reproducibly. The Reproducible Objective Quantification Scheme (ROQS) presents guidelines for selection of 15 reproducible Regions of Interest (ROI) based on anatomically identifiable structures. These ROI are applied to Diffusion Tensor Imaging (DTI) to provide estimates of anisotropy indices and diffusion coefficients. This same method is also applied to Magnetization Transfer Imaging (MTI), which provides a normalized measure (MT Ratio) of the amount of signal suppression that correlates to the type of matter being imaged. Normal volunteers (n=25) were imaged using DTI and MTI to establish population parameters for each ROI. Inter-rater reliability for the ROQS method is reported from several blind raters. This method is extended to investigate mild TBI patients imaged within the first 10 days of initial head injury. Results show sensitivity of the ROQS method to subtle forms of damage (decreased anisotropy and MTR, increased diffusion), and also capture specific forms of damage unique to each case. Thus, DTI and MTI when quantified via the ROQS approach show overall sensitivity and spatial specificity of DAI due to mild TBI.
Supported by James S. McDonnell Foundation through a collaborative grant to the Brain Trauma Foundation
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
Copyright © 2004-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
