Neuroscience 2004 Abstract
| Presentation Number: | 694.2 |
|---|---|
| Abstract Title: | Cocaine suppresses reward circuitry in lactating dams: Evidence from functional MRI and 3D computational analyses. |
| Authors: |
Kulkarni, P. P.*1
; Sullivan, J. M.1
; Harder, J. A.
; Messenger, T. L.
; Ferris, C. F.
1ME, WPI, Worcester, MA |
| Primary Theme and Topics |
Techniques in Neuroscience - Data analysis, physiological methods, statistics |
| Session: |
694. Techniques: Brain Imaging Methods II Poster |
| Presentation Time: | Tuesday, October 26, 2004 9:00 AM-10:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # FFF32 |
| Keywords: | DOPAMINERGIC |
Pups reinforcing properties are so robust that they compete with self-administration of cocaine (Hecht et al., Dev Psychobiol 35:136,1999). Indeed, postpartum dams bar press for pups in an operant response paradigm (Lee et al., Behav Brain Res 108:215, 2000). The present studies use fMRI and 3D computational analyses to compare pup-induced vs cocaine-induced changes in brain activity in lactating dams. Mothers were imaged for postnatal days 4 – 8 in response to pups (n=6) or ICV cocaine (20ug/10 ul) (n=6). A third group (n=6), imaged virgin females in response to ICV cocaine. A multi-slice fast spin echo sequence acquired twelve 1.2mm slices in 6s. All imaging consisted of 3 min (30 rep.) of control followed by 5 min (50 rep.) of stimulus. A 4.7T/40cm horiz. magnet was used.
The results for n subjects in each group were presented individually and as group composites. The analysis involved three major steps registration, segmentation and statistical analysis. Subjects were registered to a fully segmented 3D rat atlas (Kulkarni, et al. ISMRM, 4512, 2003) then segmented via the delineated atlas. Various regions (Accumbens, Prefntl Cortex, Medial Dorsal Thalamus, Ventral Pallidum, VTA, CP and Substantia Nigra) of reward system were identified. T-test analysis was performed for each subject and composite summaries were made for each category.
There was as significant positive BOLD signal in the reward pathway for dams in response to sucking and in virgin females in response to cocaine. However, cocaine administration to lactating dams caused a robust negative BOLD response throughout the dopaminergic reward pathway. These data corroborate previous findings that dams prefer pups over cocaine but also include evidence that cocaine might be “unrewarding” in the context of mother/pup interactions and bonding.
The results for n subjects in each group were presented individually and as group composites. The analysis involved three major steps registration, segmentation and statistical analysis. Subjects were registered to a fully segmented 3D rat atlas (Kulkarni, et al. ISMRM, 4512, 2003) then segmented via the delineated atlas. Various regions (Accumbens, Prefntl Cortex, Medial Dorsal Thalamus, Ventral Pallidum, VTA, CP and Substantia Nigra) of reward system were identified. T-test analysis was performed for each subject and composite summaries were made for each category.
There was as significant positive BOLD signal in the reward pathway for dams in response to sucking and in virgin females in response to cocaine. However, cocaine administration to lactating dams caused a robust negative BOLD response throughout the dopaminergic reward pathway. These data corroborate previous findings that dams prefer pups over cocaine but also include evidence that cocaine might be “unrewarding” in the context of mother/pup interactions and bonding.
Supported by NIMH R01-MH52280 & NIDA R01-DA13517DA
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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