Neuroscience 2001 Abstract
| Presentation Number: | 744.12 |
|---|---|
| Abstract Title: | ENHANCEMENT OF LEARNING IN A T-MAZE WITH INTRAHIPPOCAMPAL GLUCOSE INJECTIONS: INCREASED SELECTION OF RESPONSE STRATEGY. |
| Authors: |
Canal, C. E.*1
; Gold, P. E.1
1Dept Psychol, Univ Illinois, Champaign, IL |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Cognitive learning and memory systems |
| Session: |
744. Animal cognition and behavior: cognitive learning and memory systems: spatial learning--physiology and pharmacology Poster |
| Presentation Time: | Wednesday, November 14, 2001 11:00 AM-12:00 PM |
| Location: | Exhibit Hall SS-42 |
| Keywords: | striatum, learning and memory, neural systems, learning and memory, multiple memory systems, glucose, modulation of memory |
When trained on a T-maze that can be solved using either a hippocampus-dependent place strategy or striatum-dependent response strategy, rats tend to use a place strategy during the initial learning, but later shift to a response strategy (Packard & McGaugh, PNAS, 1996). The switch in strategy is coincident with increases in acetylcholine (ACh) release in hippocampus and striatum observed during training (Chang & Gold, SFN, 2000). Glucose (16.7 nmol) or aCSF (Ns=10) was injected bilaterally into the hippocampus of male rats prior to training on the T-maze (105 trials). To assess strategy, probe trials were included after every 15th training trial. Glucose enhanced acquisition to a criterion of 9/10 correct (p<.005). A key question was whether enhancement of learning by intrahippocampal glucose would be accompanied by delay or acceleration of the switch from place to response strategy. Nine of the ten glucose-treated rats began their sequence of criterion trials prior to the first probe trial. The glucose-treated rats showed increased selection of the response strategy as early as the first probe (glucose: 2P, 8R; aCSF: 7P,3R; p<.05), suggesting either that learning-enhanced rats acquired the task with a response strategy or that the switch in strategy had preceded the first probe trial. The latter possibility is supported by the evidence that criterion performance had begun before the first probe trial. These alternate views may be clarified by future studies of ACh release in hippocampus and striatum during learning under these conditions.
Supported by NIA (AG07648), NINDS (NS32914), USDA (00-35200-9059) & Alzheimer’s Association.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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