Neuroscience 2003 Abstract
| Presentation Number: | 662.6 |
|---|---|
| Abstract Title: | Storage and comparison of auditory durations at the human cerebellum: a functional magnetic resonance imaging study using single-shot dual-echo epi. |
| Authors: |
Mathiak, K.*1
; Hertrich, I.1
; Grodd, W.1
; Ackermann, H.1
1Univ. Tuebingen, Tuebingen, Germany |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Executive function: Working memory |
| Secondary Theme and Topics | Sensory Systems<br />- Auditory<br />-- Central physiology |
| Session: |
662. Working Memory & Executive Function IV Slide |
| Presentation Time: | Tuesday, November 11, 2003 2:15 PM-2:15 PM |
| Location: | Morial Convention Center - Room 291 |
| Keywords: | WORKING MEMORY, AUDITORY, PREFRONTAL, TIMING |
Until recently, the cerebellum was held to play its chief role in motor control. Keele and Ivry (1991) proposed that it may provide timing services subserving diverse aspects of brain function. Speech perception, which requires minute differentiation of time intervals, is compromised by cerebellar pathology and activates the right neocerebellum. In the current study, a non-speech task involving duration storage and comparison activates a lateral crus I area of the right cerebellar hemisphere (see figure). Concomitantly, a left prefrontal cluster was observed. The functional magnetic resonance imaging study employed single-shot double-echo echo-planar imaging to reduce image distortion and acquisition time with whole-brain coverage (TE = 28 and 66 ms at 1.5 T, TR = 5 sec, 28 slices, TA = 2.8 sec). Twelve healthy subjects performed two tasks: identifying pauses between tones as `short' or `long' (30-130 ms), and deciding which of two pauses was longer. The activation pattern in the discrimination task was analogous to that seen during speech perception and verbal working memory tasks. We suggest that the storage of precise temporal structures relies on a cerebellar-prefrontal loop. This network allows for temporal structuring of verbal sequences and duration categorization in a linguistic context.
Supported by DFG SFB550/B1
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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