Neuroscience 2002 Abstract
| Presentation Number: | 755.3 |
|---|---|
| Abstract Title: | DIGIT REPRESENTATION OF NOXIOUS THERMAL AND INNOCUOUS VIBROTACTILE STIMULATION IN HUMAN PRIMARY SOMATOSENSORY CORTEX: A FUNCTIONAL MRI STUDY. |
| Authors: |
Albanese, M. C.*1
; Rainville, P.2
; Coderre, T.3
; Duncan, G. H.2,4
1Dept Psychol, McGill University, Montreal, Canada 2Centre de recherche en Sciences Neurologiques, Universite de Montreal, Montreal, Canada 3Dept Anesthesia, McGill University, Montreal, Canada 4Montreal Neurological Institute, Montreal, Canada |
| Primary Theme and Topics |
Sensory Systems - Pain -- Functional imaging, psychophysics, human behavior |
| Session: |
755. Pain: psychophysics and imaging Poster |
| Presentation Time: | Wednesday, November 6, 2002 3:00 PM-4:00 PM |
| Location: | Hall A2-B3 E-103 |
| Keywords: | pain, SI, vibration, somatotopy |
The primary somatosensory cortex (SI) is widely appreciated for its somatotopic organization of responses to innocuous mechanical stimuli; however, little is known regarding the possible organization of SI responses to noxious stimulation. This within-subject fMRI study compares the spatial distribution of SI responses to innocuous and noxious stimuli presented to the fingers during psychophysical discrimination tasks. Functional MRI data were recorded during 2 separate sessions–one involving innocuous and noxious thermal stimuli (44.0°& 53.0°C) applied to digits 1 and 5, and another in which innocuous vibrotactile stimuli (75, 100, and 125Hz) were applied to the same digits.
Initial experiments demonstrate significant activation in SI for both noxious thermal and innocuous vibrotactile stimuli (p< 0.0001). Comparison of data within experimental runs demonstrates significant spatial separation of SI responses evoked by stimulation of digits 1 and 5 for both innocuous vibrotactile (X²; p< 0.0001) and noxious heat stimulation (X²; p< 0.001). Comparison of data across experimental runs within the single subject illustrates a substantially better reproducibility in the localization of vibration-related responses, compared with those observed for heat pain, suggesting a fundamental difference in the processing of these two sensory modalities within SI.
Initial experiments demonstrate significant activation in SI for both noxious thermal and innocuous vibrotactile stimuli (p< 0.0001). Comparison of data within experimental runs demonstrates significant spatial separation of SI responses evoked by stimulation of digits 1 and 5 for both innocuous vibrotactile (X²; p< 0.0001) and noxious heat stimulation (X²; p< 0.001). Comparison of data across experimental runs within the single subject illustrates a substantially better reproducibility in the localization of vibration-related responses, compared with those observed for heat pain, suggesting a fundamental difference in the processing of these two sensory modalities within SI.
Supported by CIHR, FRSQ. M.-C. A. is supported by NSERC and FCAR.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
Copyright © 2002-2026 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
