Neuroscience 2004 Abstract
| Presentation Number: | 669.8 |
|---|---|
| Abstract Title: | An fMRI investigation of the cognitive regulation of emotion in depression. |
| Authors: |
Ochsner, K. N.*1
; Robertson, E. R.2
; Ray, R. D.2
; Cooper, J. C.2
; Gabrieli, J. D. E.2
; Gross, J. J.2
; Gotlib, I. H.2
1Dept. of Psychology, Columbia Univ., New York, NY 2CA, Dept Psych Columbia University, 10027, |
| Primary Theme and Topics |
Cognition and Behavior - Motivation and Emotion |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Psychiatric Disorders<br />-- Affective disorders--Functional defecits |
| Session: |
669. Motivation and Emotion: Emotions Poster |
| Presentation Time: | Tuesday, October 26, 2004 11:00 AM-12:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # PP9 |
| Keywords: |
The ability to adaptively regulate emotion is essential for both mental and physical health, and an inability to regulate emotion plays a major role in psychiatric disorders such as depression. A particularly flexible emotion regulatory strategy is known as reappraisal, which involves controlling one’s emotional response by changing the way in which the meaning of a stimulus is interpreted. Prior work (e.g. SFN abstract Q-31, 2002), has established that the use of cognitive reappraisal to either up-regulate or down-regulate negative emotion depends upon interactions between frontal and cingulate systems that implement control processes, and emotion processing systems such as the amygdala. To date, no studies have investigated the neural systems underlying active attempts to regulate emotion in depression. To address this issue, a group of depressed adults and their matched controls down-regulated negative emotion and up-regulated positive emotion elicited by negative and positive images, respectively, while whole-brain fMRI data were collected. Trial-by-trial post-reappraisal self-reports of emotion suggest that depressed subjects and controls were able to effectively reappraise in both positive and negative conditions. Imaging results suggest both similarities and differences in the neural systems recruited by each group, with controls more effectively recruiting cognitive control systems, especially when regulating positive emotion, and depressed subjects failing to recruit right-lateralized systems used by controls. These findings have implications for understanding disorders involving emotion dysregulation.
Supported by National Institute for Mental Health
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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