Neuroscience 2001 Abstract
| Presentation Number: | 717.2 |
|---|---|
| Abstract Title: | NOCICEPTIVE RESPONSE OF NAKED MOLE-RAT: AN ANIMAL WITH SELECTIVE ABSENCE OF SUBSTANCE P AND CGRP IN SKIN. |
| Authors: |
Park, T.*1
; Laurito, C. E.1
; Rice, F.2
; Comer, C.1
; Lu, Y.1
1Biological Science, University of Illinois, Chicago, IL 2Anesthesiology, University of Illinois, Chicago, IL |
| Primary Theme and Topics |
Sensory Systems - Pain Modulation -- Opiods, cannabinoids and other peptides and receptors |
| Secondary Theme and Topics | Sensory Systems<br />- Pain<br />-- Somatic, muscle and visceral: Nociceptive receptors |
| Session: |
717. Pain modulation: peptides and receptors Poster |
| Presentation Time: | Wednesday, November 14, 2001 9:00 AM-10:00 AM |
| Location: | Exhibit Hall G-25 |
| Keywords: | pain, neuropeptide |
Naked mole-rats lack substance P and CGRP in cutaneous nerve fibers, and dorsal root ganglia cells (SFN Abs 2000, 26 p 126). These peptides are thought to be neurotransmitters released from capsaicin-sensitive C polymodal nociceptors. The present experiments were designed to investigate the effects of natural SP and CGRP absence on the nociception, and to determine whether C-fiber or A-delta nociceptor activity is differentially affected by the absence of these peptides. We used foot withdrawal to noxious heating, and the formalin test. In skin heating, high rates of heating predominantly activate A-delta fibers. Low rates of heating predominantly activate C fibers, which can be sensitized by topical application of a low dose of capsaicin, shortening withdrawal latency. In naked mole-rat skin, capsaicin application (2nM or 10nM) caused no changes in presumptive C-fiber mediated withdrawal compared to control rats and mice. In the formalin test (1% 50ml), naked mole-rats, compared to mice, showed significantly lower scores for the immediate phase (0-5min) of nociceptive response, associated with C-fiber activity, but not for later, persistent pain. These results, in conjunction with our previous immunolabeling results, indicate that SP and CGRP play an important role in nociceptive responses mediated by C-fibers, and that absence of these peptides selectively effect C-fiber activation, but not A-delta fiber transmitted nociception. Hence, the naked mole-rat should be of great use as a genetic animal model to distinguish the underlying mechanisms of fast pain and slow pain.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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