Neuroscience 2004 Abstract
| Presentation Number: | 642.9 |
|---|---|
| Abstract Title: | Spatial specificity of gradient echo (ge) bold and spin echo (se) bold functional mri in cat visual cortex at 94 t. |
| Authors: |
Park, J. C.*1
; Ronen, I.1,2
; Ugurbil, K.1
; Dae-Shik, K.1,2
1Radiology (CMRR), Univ. of Minnesota Med. Sch., Minneapolis, MN 2MA, 2021 6th St. Se, 55455, |
| Primary Theme and Topics |
Sensory Systems - Tactile/Somatosensory -- Cortex imaging |
| Session: |
642. Cortex Imaging I Poster |
| Presentation Time: | Tuesday, October 26, 2004 8:00 AM-9:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # W5 |
| Keywords: | point spread function, retinotopic border |
Functional MRI (fMRI) has become the most commonly used non-invasive brain imaging technique. With the growing interest in neuroscience applications using fMRI, it became crucial to understand the specificity of its signal with respect to the actual neuronal response. We recently reported a comparison of point spread functions (PSF) of GE BOLD and CBF based fMRI in cat visual cortex (area 18), which provided a quantitative relationship between spatial specificities of both fMRI modalities. In this study we addressed the PSFs of GE BOLD and SE BOLD fMRI at an ultra-high magnetic field, 9.4 T and compared them to the previous results. The PSF was obtained by delivering stimuli that alternately evoked responses from the upper and the lower visual fields. Thus it generated a “retinotopic border” between two adjacent areas in the primary visual cortex. By examining the statistical maps in the region of the retinotopic border and in particular the profiles of the activation maps perpendicular to the border, we estimated the PSFs of both techniques. The PSFs of GE BOLD and SE BOLD fMRI were approximately 1.6 mm and 1.0 mm, respectively. It is postulated that specificity of the SE BOLD fMRI is increased, because SE BOLD fMRI at high fields is sensitive to changes originating from microvasculature. This result and the previous result suggest that the SE BOLD technique is better suited for high-resolution investigation of cortical organization in brain than GE BOLD, but the CBF technique is more spatially localized than SE BOLD fMRI.
Supported by: NIH (RR08079, MH61937, MH67530), The Keck Foundation, The MIND institute, and The Whitaker Foundation.
Supported by: NIH (RR08079, MH61937, MH67530), The Keck Foundation, The MIND institute, and The Whitaker Foundation.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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