Neuroscience 2004 Abstract
| Presentation Number: | 596.1 |
|---|---|
| Abstract Title: | Differential roles for prefrontal and hippocampal regions: A functional MRI study comparing successful encoding of items and associations. |
| Authors: |
Chua, E. F.*1,2
; Schacter, D. L.1
; Rand-Giovannetti, E.3
; Driscoll, A.2
; Sperling, R. A.1,2,3
1Harvard Univ., Cambridge, MA 2MA, William James Hall, Psychology, 02138, 3USA, William James Hall, Psychology, 02138, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Learning and long-term memory |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human and Animal Cognition and Behavior<br />-- Learning & memory: Physiology and imaging |
| Session: |
596. Learning and Long-Term Memory VI Slide |
| Presentation Time: | Tuesday, October 26, 2004 8:00 AM-8:15 AM |
| Location: | San Diego Convention Center - Room 7B |
| Keywords: |
Our previous research has shown that the left prefrontal cortex and anterior medial temporal lobes (MTL) are important for the formation of successful associations. In this study, we used an identical encoding task to our earlier paradigm, which was scanned on a Siemens 3T, followed by a different post-scan test in order to compare successful encoding of items and associations. During encoding, 19 subjects (15 F/4M, mean age 24.15 +/- 3.25) were scanned on a GE 3T while viewing 455 novel face-name pairs. Post-scan, subjects viewed all 455 faces seen during encoding plus 200 distracter faces and made an old/new decision followed by a confidence rating. Subjects then chose which of two names was previously paired with the face and indicated their confidence level. Random effects group averages for fMRI data were generated in SPM2 and thresholded at p<0.005, 5 voxel extent. Analyses analogous to our previous study revealed a similar pattern of activation in the MTL and left prefrontal cortex related to the successful encoding of face-name associations. Specific to this study, we showed that memory for the face alone was primarily driven by activation in the right prefrontal cortex (MNI: 46, 34, 14) and that MTL activation was apparent only at a lower threshold (left: -24, -16, -22; right: 20, -28, -12; p<0.01). Further comparisons for trials on which the face was remembered showed greater activation in the left anterior MTL (-28, -4, -24) when the associated name was remembered than when it was forgotten. These findings suggest that formation of item-specific memory for faces primarily activates the right prefrontal cortex and it is the formation of face-name associations that drives the activation in the anterior MTL.
Supported by K23-NS02189; P01-AG04953; AFAR Beeson Scholars in Aging; HCNR
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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