Neuroscience 2000 Abstract
| Presentation Number: | 639.7 |
|---|---|
| Abstract Title: | Who's your daddy? BrdU dating of different classes of GABA neurons in the medial prefrontal cortex. |
| Authors: |
Stadler, J. R.*1
; Deutch, A. Y.1
1Department of Psychology, Vanderbilt University, Nashville, TN |
| Primary Theme and Topics |
G. Motor Systems and Sensorimotor Integration - 86. Cortex and thalamus |
| Secondary Theme and Topics | A. Development and Regeneration<br />- 20. Cerebral cortex and limbic system |
| Session: |
639. Cortex and thalamus: functional anatomy Poster |
| Presentation Time: | Wednesday, November 8, 2000 10:00 AM-11:00 AM |
| Location: | Hall G-J |
| Keywords: | Interneuron, Calbindin, Parvalbumin, Calretinin |
The present study investigated when different classes of GABA-containing interneurons in the medial prefrontal cortex (PFC) were generated during prenatal and postnatal development. Pregnant female rats were injected with bromodeoxyuridine (BrdU) at different gestation times ranging from embryonic day 12 (E12) to 21. In addition, newborn male rat pups were injected at post-natal days 3, 7, and 14. Rats were allowed to mature to 75-90 days old before they were perfused with a 4% paraformaldehyde solution, their brains were removed and tissue was processed to reveal both BrdU and one of the calcium-binding proteins: calbindin (CB), calretinin (CR), or parvalbumin (PV). Double-labeled cells first appeared after E12, continued to be present through E19, and were no longer evident thereafter. The distribution of double-labeled cells across development differed among the subtypes of GABAergic neurons. The number of double-labeled PV-containing neurons peaked at E14 and remained at comparable levels until E17-E18. The number of double-labeled CB-containing neurons peaked around E16-17, whereas the number of double-labeled CR-containing neurons peaked at E15-E16. Knowledge of the normal developmental profile of the GABAergic neurons in the mPFC may provide clues to developmental problems which can contribute to such disorders as schizophrenia.
Supported by MH-57995, MH-45124, and a NARSAD Distinguished Investigator Award.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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