Neuroscience 2000 Abstract
| Presentation Number: | 639.3 |
|---|---|
| Abstract Title: | 3-D cytoarchitectonic parcellation of the human thalamus: correlation with postmortem MRI. |
| Authors: |
Smeets, W. J. A.*1
; de Vos, K.2
; Pool, C. W.2
; Zilles, K.3,4
; Uylings, H. B. M.1,2
1Dept Anat, Vrije Universiteit, Amsterdam 1081 BT, The Netherlands 2Netherlands Institute for Brain Research, Amsterdam, The Netherlands 3C.& O. Vogt Institute for Brain Research, Dusseldorf, Germany 4Institute of Medicine Julich Research Center, Julich, Germany |
| Primary Theme and Topics |
G. Motor Systems and Sensorimotor Integration - 86. Cortex and thalamus |
| Session: |
639. Cortex and thalamus: functional anatomy Poster |
| Presentation Time: | Wednesday, November 8, 2000 10:00 AM-11:00 AM |
| Location: | Hall G-J |
| Keywords: | imaging, diencephalon, mapping |
For a more accurate determination of a thalamic lesion or target for neurosurgical intervention as well as for a better interpretation of functional MRIs and PET studies, we are currently preparing a 3-D atlas of the human thalamus. For the present study, 5 brains have been used from human subjects without known neurological or psychiatric deficits. Postmortem MRIs were taken before brains were paraffin embedded, cut in the frontal plane at a thickness of 20 μm and stained with Gallyas modification for neuronal cell bodies. Cytoarchitectonic criteria, in particular cell density, cell size and shape, as well as arrangement of cells, were used to delineate the various thalamic nuclei in sections taken at an interval of about 1 mm. The mammillary bodies, mammillothalamic tract, habenula, subthalamic nucleus, and nucleus ruber were included in the 3-D atlas as additional landmarks. The Gallyas-stained sections with the delineated cell masses were superimposed on the postmortem 3-D MRIs after local affine transformation of histological sections onto MRI sections. Frontal sections, at three levels (rostral, intermediate, caudal) are presented to show the position of about 10 major out of the 40 delineated thalamic nuclei. In addition, 3-D reconstructions of some of these nuclei are shown. The present data will be incorporated in the ongoing study of interindividual variability of thalamic nuclei and in the European 3-D Human Brain Atlas and Database.
Supported by Biotech (EU) grant BIO-CT96-0177 (KZ, HBMU)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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