Neuroscience 2000 Abstract
| Presentation Number: | 639.2 |
|---|---|
| Abstract Title: | Functional specialization within primary motor cortex: direct correlation between functional MRI and chemoarchitectonics. |
| Authors: |
Solodkin, A.*1,2
; Hlustik , P.1,2
; Small, S. L.1,2
1Department of Neurol, The University of Chicago, Chicago, IL 2Brain Research Imaging Center, The University of Chicago, Chicago, IL |
| Primary Theme and Topics |
G. Motor Systems and Sensorimotor Integration - 86. Cortex and thalamus |
| Secondary Theme and Topics | G. Motor Systems and Sensorimotor Integration<br />- 93. Control of posture and movement |
| Session: |
639. Cortex and thalamus: functional anatomy Poster |
| Presentation Time: | Wednesday, November 8, 2000 9:00 AM-10:00 AM |
| Location: | Hall G-J |
| Keywords: | IMAGING, MOTOR CORTEX, CYTOARCHITECTURE, PREMOTOR |
Our functional MRI studies of complex finger movements in normal subjects have demonstrated two distinct loci of activity on the anterior bank of the central sulcus in primary motor cortex (M1). The first site is located on the knob formed by the inter-digitation of M1 and primary sensory cortex (S1), and the second is found lateral to this knob. The question then arises as to whether these functionally distinct areas share the same neuroanatomical features and whether or not both are part of M1. In order to relate our functional observations to the cyto- and chemoarchitecture of these areas, we imaged (T1-weighted MRI) post-mortem tissue and then performed basic neuroanatomy with Nissl histochemistry and immunohistochemistry for calcium binding proteins (calbindinD28 and parvalbumin) and a non-phosphorylated neurofilament protein (SMI-32). While brain activation in the medial location was clearly embedded in M1, the lateral site was difficult to assess cyto- and chemoarchitectonically. This was due to a decrease in the density of Betz cells, and a pattern of calcium-binding proteins that was intermediate between the lateral pre-motor cortex (LPMC) and M1. It is clear that these two functional motor areas have different underlying anatomical features. With these results, however, we can not classify the lateral site as either M1 or LPMC since it resembles both. The presence of such hibrid architectonic features suggests that this transitional region may be an isolable zone that plays a distinct functional role.
Supported by NIH NS 37195 (SLS) and NIH MH 01916 (AS)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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