Neuroscience 2004 Abstract
| Presentation Number: | 577.3 |
|---|---|
| Abstract Title: | Induction of δFosB by drugs of abuse. |
| Authors: |
Perrotti, L. I.*1
; Elmore, R. G.1
; Ulery, P. G.1
; Edwards, S.1
; Choi, K. H.1
; Winstanley, C. A.1
; Barrot, M.1
; Selley, D. E.2
; Sim-Selley, L.2
; Self, D. J.1
; Nestler, E. W.1
1Dept Psychiatry, Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 2VA, 5323 Harry Hines Blvd, 75390-9070, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Addiction: neurobiology |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Addiction and Drugs of Abuse<br />-- Neurobiology of reward |
| Session: |
577. Addiction: Neurobiology II Poster |
| Presentation Time: | Monday, October 25, 2004 3:00 PM-4:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # DDD18 |
| Keywords: |
ΔFosB has been shown to accumulate and persist in the brain in response to chronic stimulation. This accumulation after chronic exposure to drugs of abuse has been demonstrated previously by Western blot in several brain regions, including the nucleus accumbens, dorsal striatum, amygdala, and prefrontal cortex. In the present study, we used immunohistochemistry to define with greater anatomical precision the induction of ΔFosB after chronic drug treatment. We used two antibodies: one that recognizes both ΔFosB and FosB, and another that only recognizes FosB. We mapped the reward-relevant brain regions showing ΔFosB induction after chronic drug administration. Animals received one of five chronic drug treatments: investigator-administered cocaine, self-administered cocaine, investigator-administered morphine or Δ9-THC, or self-administered ethanol. Each drug treatment increased the number of ΔFosB immunoreactive cells in a region-specific manner in brain. All treatments induced ΔFosB in the nucleus accumbens, although some differences were seen. For example, cocaine induced ΔFosB in both the core and shell subregions, while morphine produced this effect in the core subregion only. Drug treatments also differed in their induction of ΔFosB within specific subregions of frontal cortex. Additionally, only cocaine induced ΔFosB expression in the posterior VTA. Experiments are underway to complete the mapping of ΔFosB induction in brain for all of these treatments, and to investigate the nature of these ΔFosB positive cells. This work is a critical first step toward understanding the role played by ΔFosB in each of the brain regions involved in drug addiction.
Supported by NIDA
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
Copyright © 2004-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
