Neuroscience 2001 Abstract
| Presentation Number: | 643.12 |
|---|---|
| Abstract Title: | A LONG DAY'S JOURNEY INTO NIGHT. |
| Authors: |
Gerrard, J. L.*1
; Bower, M. R.1
; Insel, N.1
; Lipa, P.1
; Barnes, C. A.1
; McNaughton, B. L.1
1Neural Systems, Memory & Aging, Univ. Arizona, Tucson, AZ |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning & memory: Physiology and imaging |
| Session: |
643. Animal cognition and behavior: learning and memory--physiology and imaging IV Poster |
| Presentation Time: | Tuesday, November 13, 2001 4:00 PM-5:00 PM |
| Location: | Exhibit Hall TT-48 |
| Keywords: | hippocampus, place cells, memory, consolidation |
Are patterns of coactivity of hippocampal neurons selected at random, or is there a propensity for some cells to exhibit strong correlations over many different experiences? This question has been the subject of controversy for several decades. Most studies have been performed in one or a few rather small environments in which the sample of the possible state space of the network is small. CA1 pyramidal cell activity was recorded while rats walked down and back along a long (13m x 2m) corridor. Few locations were visited more than once. As predicted by the random allocation model, the variance of the distribution of firing rate correlations became compressed around zero as compared to typical periods of repetitive track running. Moreover, the distribution of mean firing rates became significantly less sparse, again in agreement with the random model. This suggests that synaptic weight vectors of CA1 pyramidal cells are essentially uncorrelated. The degree of memory trace reactivation (Wilson and McNaughton, Science, 265:676-679, 1994; Kudrimoti et al., J. Neurosci., 19:4090-4101, 1999) was also assessed during sleep following the long corridor experience, and compared to rats which ran repetitively around a small track. The population vector overlap between behavior and subsequent sleep, and the percent of the firing rate correlation variance during sleep that was statistically explained by the pattern during behavior (robust measures of reactivation) were significantly lower in the long corridor experiment than for the typical case of repetitious behavior, suggesting that repetition facilitates memory trace reactivation.
Supported by AG12609, MH01565, MH46823 & ARCS
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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