Neuroscience 2001 Abstract
| Presentation Number: | 642.4 |
|---|---|
| Abstract Title: | EFFECTS OF SELECTIVE HIPPOCAMPAL LESIONS AND TARGET PRETRAINING ON SERIAL FEATURE NEGATIVE DISCRIMINATION. |
| Authors: |
Chan, K. H.*1
; Tracy, A. L.1
; Jarrard, L. E.2
; Davidson, T. L.1
1Purdue University, Lafayette, IN 2Washington & Lee University, Lexington, VA |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Associative, nonassociative and skill learning & memory systems |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Learning & memory: Physiology and imaging |
| Session: |
642. Animal cognition and behavior: associative, nonassociative and skill learning and memory systems--conditioning and nonassociative learning Poster |
| Presentation Time: | Tuesday, November 13, 2001 4:00 PM-5:00 PM |
| Location: | Exhibit Hall TT-30 |
| Keywords: | association, inhibition, learning, memory |
Previously, Holland et al. (Hipp, 9: 143-157, 2000) reported that acquisition of an appetitive serial feature negative (FN) discrimination (A+, B-->A-) was impaired for rats with excitotoxic lesions of the hippocampus. However, other experiments failed to replicate this finding (e.g., Morell, et al., SFN Abst, 2000). In the study by Holland et al., a relatively high level of responding was observed to the target from the outset of training. In the present experiment, we used pretraining (A+) to elevate responding to the target, prior to FN training. We then assessed the effects of pretraining on the ability of rats with ibotenate hippocampal lesions to solve the FN discrimination. Following pretraining with the target, rats with hippocampal lesions showed superior FN performance relative to controls. This enhancement was reduced for hippocampal rats that had been pretrained with a target different than the target used during FN training. The results of a summation test suggested that for both lesioned rats and controls, the feature functioned as an occasion setter rather than a conditioned inhibitor. During a retardation test, simple excitatory training of the feature (B+) produced more rapid acquisition of conditioned responding for hippocampal rats than for controls. However, this effect was limited to rats that were not pretrained with the target used in feature negative training. The results indicate that although hippocampal damage does not interfere with FN discrimination performance, there may be differences between hippocampal and control rats in the amount or the type of inhibition learning during serial FN discrimination.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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