Neuroscience 2001 Abstract
| Presentation Number: | 624.5 |
|---|---|
| Abstract Title: | A Direct Cortical Stimulation Model for Rodent fMRI. |
| Authors: |
Austin, V.*1,2
; Sibson, N.2
; Blamire, A.2
; Matthews, P.1
1FMRIB Centre, Univ Oxford, Oxford, United Kingdom 2Dept of Biochem, Univ Oxford, Oxford, United Kingdom |
| Primary Theme and Topics |
Motor Systems - Cortex and Thalamus -- Imaging |
| Session: |
624. Cortex and thalamus: imaging--activity Poster |
| Presentation Time: | Tuesday, November 13, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall EE-2 |
| Keywords: | functional, MRI, BOLD, motor cortex |
Our objective has been to develop a direct cortical stimulation model for rodent functional magnetic resonance imaging (fMRI). Conventional fMRI studies in anaesthetised rodents are limited to the study of the somatosensory cortex via remote stimulation.
Our approach has been to stimulate directly with stereotaxically placed carbon fibre electrodes over the hindpaw motor cortex in the rat to elicit movement of the contralateral limb. Using a 7T MRI system, blood oxygenation-level dependent (BOLD) signal changes can be detected using T2* weighted gradient echo imaging, to indicate which cortical areas are functionally active during stimulation.
The most prominent signal changes occur in the region of the stimulated motor cortex. As with somatosensory responses, the haemodynamic response function timecourse is prolonged. This model of direct cortical stimulation will enable brain connectivity, functional recovery after injury, and drug responses to be investigated.
Our approach has been to stimulate directly with stereotaxically placed carbon fibre electrodes over the hindpaw motor cortex in the rat to elicit movement of the contralateral limb. Using a 7T MRI system, blood oxygenation-level dependent (BOLD) signal changes can be detected using T2* weighted gradient echo imaging, to indicate which cortical areas are functionally active during stimulation.
The most prominent signal changes occur in the region of the stimulated motor cortex. As with somatosensory responses, the haemodynamic response function timecourse is prolonged. This model of direct cortical stimulation will enable brain connectivity, functional recovery after injury, and drug responses to be investigated.
Supported by Medical Research Council and Eli Lilly & Co Ltd
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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