Neuroscience 2002 Abstract
| Presentation Number: | 634.17 |
|---|---|
| Abstract Title: | Spontaneous recovery of the sensory system after spinal cord injury; a functional MRI study. |
| Authors: |
Hofstetter, C. P.*1
; Schweinhardt, P.1
; Spenger, C.1
; Olson, L.1
1Dept Neuroscience, Karolinska Institiutet, Stockholm, Sweden |
| Primary Theme and Topics |
Development - Transplantation and Regeneration -- Regeneration: CNS |
| Session: |
634. Transplantation and regeneration: cellular mechanisms I Poster |
| Presentation Time: | Wednesday, November 6, 2002 8:00 AM-9:00 AM |
| Location: | Hall A2-B3 B-107 |
| Keywords: | REGENERATION, FUNCTIONAL MRI, SOMATOSENSORY, NEUROIMAGING |
Spontaneous recovery after spinal cord injury is limited. After an incomplete spinal cord injury, however, significant functional recovery occurs, probably due to synaptic plasticity and formation of new circuits. Compared to the motor systems, little is known about regeneration and/or plasticity in the sensory system after spinal cord injury. Therefore we designed methods to explore functional and structural plasticity of sensory pathways following contusion injury of the spinal cord by means of functional MRI and behavioral tests. Rats received a weight drop injury (12.5 or 6.25 mm) and were tested after 1, 4 or 16 weeks. Functional MRI using the BOLD technique in response to electric stimulation of the hindlimbs, gave rise to signals in sensorimotor cortex. The monitored BOLD signals were compared to different behavioral tests, such as BBB, gridway and hotplate.
The results suggest a discrepancy between motor and sensory recovery.
Thus animals with complete loss of sensation could show a high degree of motor function as revealed by BBB scoring during the first four weeks after injury. Recovery of the sensory system was observed at 16 weeks as assessed by fMRI, gridway and hotplate.
The results emphasize the importance of monitoring hindlimb sensory function in experimental spinal cord injury and repair research.
The results suggest a discrepancy between motor and sensory recovery.
Thus animals with complete loss of sensation could show a high degree of motor function as revealed by BBB scoring during the first four weeks after injury. Recovery of the sensory system was observed at 16 weeks as assessed by fMRI, gridway and hotplate.
The results emphasize the importance of monitoring hindlimb sensory function in experimental spinal cord injury and repair research.
Supported by Swedish MFR K2002-73X-13404-03A
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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