Neuroscience 2001 Abstract
| Presentation Number: | 608.15 |
|---|---|
| Abstract Title: | CONTINGENT AND NON-CONTINGENT PREFEEDING OF SUCROSE DIFFERENTIALLY AFFECTS RAT DOPAMINE TRANSPORTER. |
| Authors: |
Bello, N. T.*1,2
; Sweigart, K. L.3
; Lakoski, J. M.1,3
; Norgren, R.1,2
; Hajnal, A.1,2
1Neuroscience Program, College of Medicine, Penn State University, Hershey, PA 2Behavioral Science, College of Medicine, Penn State University, Hershey, PA 3Pharmacology and Anesthesiology, College of Medicine, Penn State University, Hershey, PA |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Transporters -- Monoamines, GABA, et3. |
| Secondary Theme and Topics | Cognition and Behavior<br />- Behavioral Pharmacology<br />-- Monoamines and behavior |
| Session: |
608. Transporters: dopamine I Poster |
| Presentation Time: | Tuesday, November 13, 2001 3:00 PM-4:00 PM |
| Location: | Exhibit Hall F-23 |
| Keywords: | feeding, anticipation, nucleus accumbens, ventral tegmental area |
Using microdialysis we previously reported that prior sucrose licking enhanced accumbens dopamine (DA) turnover in response to feeding (SFN Abst. 26: 2249, 2000). To determine if this effect was related to changes in dopamine transporter (DAT) activity, we used a similar paradigm and measured binding of a specific DAT radioligand ([I125]-RTI155) in different brain regions. Rats that were food and water deprived overnight received 20 min access to 0.3M sucrose at 10 a.m. followed 2h later with food for 20 min (Contingent group, n=12). The controls randomly received either 0.3M sucrose, or food, or no stimulus (Non-contingent group, n=12). On day 7 of training, both groups were subdivided and sacrificed either before or after the 20-min feeding session. In the nucleus accumbens (NAcc) and in the ventral tegmental area (VTA), [I125]-RTI55 binding was lower in the Contingent than in the Non-contingent group just before ingestion (-38%, p<0.01). After the ingestion period, DAT binding in the NAcc and in the VTA increased in the Contingent group (+19%, +32%, respectively), but decreased in the Non-contingent rats (-30%, -45%, respectively). These results support the hypothesis that experience with prior ingestion of a preferred substance results in lasting changes in DA mechanisms both before and after an expected meal.
Supported by PHS grants, DC00240, DC04751, AG17477.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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