Neuroscience 2005 Abstract
| Presentation Number: | 547.2 |
|---|---|
| Abstract Title: | A volumetric MRI study of the hippocampus and the parahippocampal region after unilateral temporal lobe resection. |
| Authors: |
Noulhiane, M.*1
; Samson, S.2
; Clémenceau, S.3
; Dormont, D.4
; Tallon-Baudry, C.1
; Baulac, M.5
; Hasboun, D.4
1LENA CNRS UPR 640, Paris, France 2France, hôpital de la Salpêtrière, 47 bd de l'hôpital, 75651, 3Epilepsy Unit, hôpital de la Salpêtrière, 47 bd de l'hôpital, 75651, 4Neurosurgery Unit, hôpital de la Salpêtrière, 47 bd de l'hôpital, 75651, 5INSERM U739 cortex and épilepsie, Neuroradiology Unit, |
| Primary Theme and Topics |
Disorders of the Nervous System - Epilepsy -- Human studies and animal models |
| Secondary Theme and Topics | Techniques in Neuroscience<br />- Data Analysis and Statistics |
| Session: |
547. Epilepsy: Animals and Human Poster |
| Presentation Time: | Monday, November 14, 2005 2:00 PM-3:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # RR11 |
| Keywords: | medial temporal lobe, epilepsy surgery, MRI volumetric analysis |
This anatomical study presents MRI-based volumetric analysis of all structures of the Medial Temporal Lobe (MTL) including the hippocampus, the amygdala, the temporopolar cortex and the parahippocampal gyrus (perirhinal, entorhinal and parahippocampal cortices) spared after unilateral MTL removal carried out for the treatment of drug-refractory temporal-lobe epilepsy. Such methods already applied to epileptic patients before surgery, have not been used after surgical treatment.
Based on the location of the remaining anatomical landmarks, we quantified the volume of all these regions in 40 patients after unilateral MTL resection (right: N= 20; left: N = 20) and in 16 control participants using MRI-based volumetric analysis.
The results showed that (1) the mean volumes of these regions contralateral to the epileptic focus were similar to those measured from normal subjects (2) the volumetric measures obtained from the resected side were obviously reduced compared to those from the non-resected side or from normal values and (3) the extent of MTL resection was comparable in right or left MTL surgery. Individual differences noted across the patient samples were also analyzed and showed that the parahippocampal cortex, as opposed to the other regions, was not systematically removed.
The segmentation guidelines presented here should provide a useful tool to study the specific involvement of the distinctive MTL structures in surgical outcomes and in human cognition such as memory and emotional processes, in complementary to electrophysiological and functional neuroimaging researches.
Based on the location of the remaining anatomical landmarks, we quantified the volume of all these regions in 40 patients after unilateral MTL resection (right: N= 20; left: N = 20) and in 16 control participants using MRI-based volumetric analysis.
The results showed that (1) the mean volumes of these regions contralateral to the epileptic focus were similar to those measured from normal subjects (2) the volumetric measures obtained from the resected side were obviously reduced compared to those from the non-resected side or from normal values and (3) the extent of MTL resection was comparable in right or left MTL surgery. Individual differences noted across the patient samples were also analyzed and showed that the parahippocampal cortex, as opposed to the other regions, was not systematically removed.
The segmentation guidelines presented here should provide a useful tool to study the specific involvement of the distinctive MTL structures in surgical outcomes and in human cognition such as memory and emotional processes, in complementary to electrophysiological and functional neuroimaging researches.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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