Neuroscience 2004 Abstract
| Presentation Number: | 534.5 |
|---|---|
| Abstract Title: | Bilaterally projecting cortico-striatal pathway is activated on the stepping-pattern learning in mice. |
| Authors: |
Kitsukawa, T.*1
; Yanagihara, D.2
; Yamamori, T.1
1Speciation Mechanism 1, Nat'l Inst Basic Biol, Okazaki, Japan 2Japan, 38 Nishi-Gonaka, Myodaiji, 444-8585, |
| Primary Theme and Topics |
Motor Systems - Basal Ganglia -- Behavior |
| Secondary Theme and Topics | Motor Systems<br />- Basal Ganglia<br />-- Cellular networks |
| Session: |
534. Basal Ganglia: Behavior II Poster |
| Presentation Time: | Monday, October 25, 2004 1:00 PM-2:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # Z9 |
| Keywords: | STRIATUM, MOTOR LEARNING, MOTOR CONTROL, MOTOR CORTEX |
To understand neuronal circuits concerning motor skill learning we built a wheel running system in which mice learn stepping-patterns. This motor learning system consists of a wheel turning at a constant speed with pegs on which mice run. The mice deprived of water in their home cages were trained to keep running on the pegs to drink water from a spout. When the peg-pattern was changed from a complicated pattern to another, the mice are required to adjust their stepping-pattern to the new peg-pattern. Using this system we reported that mice could learn these complicated stepping–patterns and c-Fos expression was increased in the motor cortices and the dorsolateral striatum on the day of stepping-pattern learning (264.8, 32nd SfN meeting, 2002). In this study, we investigated what type(s) of neuronal inputs to the striatum was activated by the peg-pattern change. We injected DiI into the dorsolateral striatum, and examined c-Fos expression in retrogradely labeled neurons. DiI labeled neurons were found in the neocortex, thalamic nuclei and substantia nigra pars compacta. c-Fos expression in the DiI labeled neurons was found mainly in the motor cortex. We compared c-Fos expression in the mouse brains on the first day of the peg-pattern change to those of seventh day after the change, and found that the c-Fos expression was significantly increased in the contralateral cortex compared to the DiI injected striatum on the first day. There are at least two types of cortico-striatal projection neurons, 1) the unilaterally projecting neurons which are considered as pyramidal tract neurons and 2) the bilaterally projecting neurons which send axons to the striatum and cortex bilaterally. Our results suggest that the bilaterally projecting cortico-striatal neurons were specifically activated upon the peg-pattern change and may play a role in the motor skill learning.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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