Neuroscience 2000 Abstract
| Presentation Number: | 569.15 |
|---|---|
| Abstract Title: | Effects of the cannabinoid antagonists AM 630 and AM 281 on deprivation-induced food intake in Lewis rats. |
| Authors: |
Koch, J. E.*1
; Werner, N. A.1
1Dept Psychol, Univ Wisconsin, Oshkosh, Oshkosh, WI |
| Primary Theme and Topics |
I. Neural Basis of Behavior - 115. Ingestive behaviors |
| Secondary Theme and Topics | D. Neurotransmitters, Modulators, Transporters, and Receptors<br />- 54. Cannabinoids |
| Session: |
569. Ingestive behaviors: metabolic regulators Poster |
| Presentation Time: | Tuesday, November 7, 2000 3:00 PM-4:00 PM |
| Location: | Hall G-J |
| Keywords: | Cannabinoids, Lewis rats, Ingestion, CB1 Receptors |
The present study extends the link between food intake and cannabinoid substances, specifically two cannabinoid antagonists AM 630 and AM 281. Previous studies from our lab have focused on the stimulatory effects of delta9-tetrahydrocannabinol (THC) in Lewis rats (SFN abstract 847.18, 1998 and SFN abstract 749.17, 1999), which are responsive to appetite-stimulating effects of THC alone and when combined with lateral hypothalamic stimulation (Trojinar & Wise, 1991). The current research examined the potential of cannabinoid antatonists to affect food intake induced by food deprivation. Following establishment of baseline deprivation-induced chow intake (deprivation was 12 h overnight) male Lewis rats (N=20) were divided into two groups of 10, each of which received intracerebroventricular (i.c.v ) injections of either AM 630 or AM 281 at doses of 0 (veh = 4% DMSO) 2.5, 5, 10 and 20 ug (all in 10 ul volumes) following overnight food deprivation. Food intake was measured at 0.5, 1, 2, 4 & 6h following injections. AM 630 had virtually no effects on deprivation-induced intake at any of the time periods following i.c.v. administration, and in fact a significant increase over vehicle was seen at 6h following the 5 ug dose. AM 281 significantly and dose-dependently decreased deprivation-induced intake compared to vehicle at 0.5h (all doses), 1h (5, 10 & 20 ug) and at 2, 4 & 6h (20 ug). Results are discussed with respect to cannabinoid receptor systems' involvement in ingestion and the differential pharmacological profiles of AM 630 and AM 281.
Supported by Univ. WI Oshkosh Psychology Department and by a grant from Univ. WI Oshkosh faculty development program (FDR714).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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