Neuroscience 2003 Abstract
| Presentation Number: | 500.8 |
|---|---|
| Abstract Title: | cAMP mediates bursting in a neuron modulated by a peptide CO-transmitter. |
| Authors: |
Wood, D. E.*1
; Brown, B. E.1
1Dept. Biol, Case Western Reserve Univ, Cleveland, OH |
| Primary Theme and Topics |
Motor Systems - Invertebrate Motor Systems |
| Secondary Theme and Topics | Motor Systems<br />- Pattern Generation and Locomotion |
| Session: |
500. Invertebrate Motor Systems Pattern Generation Poster |
| Presentation Time: | Monday, November 10, 2003 4:00 PM-5:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # I22 |
| Keywords: | central pattern generator, neuromodulation, invertebrate, stomatogastric nervous system |
Dynamics in intracellular signaling underlie modulatory processes in neurons. We are examining the role of co-transmitters in modulating a bursting neuron that is part of a multifunctional pattern generator. The stomatogastric nervous system (STNS) of crustaceans is the rhythmic pattern generating network underlying swallowing, chewing, and filtering of food. Distinct but overlapping circuits compose the pattern generating circuits of the STNS, and the gastric mill circuitry is responsible for chewing behavior. The lateral gastric neuron (LG) is an identified neuron that is part of a reciprocally inhibitory pair of neurons pivotal to gastric mill pattern generation (Coleman et al., Nature 1995). We have demonstrated that a plateau potential supports LG bursting as elicited by an identified projection neuron (modulatory commissural neuron 1, MCN1) (see Brown and Wood, SFN Abstr, 2003). Crab tachykinin related peptide Ia (CabTRPIa), one of the three identified co-transmitters in MCN1 that include proctolin and GABA , modulates the activity of LG (Wood et al., J Neurosci, 2000; Blitz et al. J Comp Neur, 1999). Spantide I (a CabTRPIa receptor blocker) inhibits the MCN1 induced plateau potentials in LG. Bath application of forskolin (50 mM) (an adenylyl cyclase activator) induces LG activity. The plateau is reinstated in the presence of forskolin plus spantide. This implies that CabTRPIa modulates the LG plateau potential through a cAMP mediated mechanism. We are currently investigating the temporal dynamics of cAMP concentration elevation during LG rhythmic bursting and the potential roles for proctolin and GABA in mediating intracellular signaling.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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