Neuroscience 2000 Abstract
Presentation Number: | 559.1 |
---|---|
Abstract Title: | Functional MRI in individuals in memory loss. |
Authors: |
Mandzia, J. L.*1,5
; Black, S. E.2,3
; Grady, C.3,5
; McAndrews, M.4,5
; Graham, S.2,5
1Institute of Medical Science, Toronto, Canada 2Sunnybrook & Women's , Toronto, Canada 3Rotman Research Institute, Baycrest Centre, Toronto, Canada 4University Health Network, Toronto, Canada 5University of Toronto, Toronto, Canada |
Primary Theme and Topics |
I. Neural Basis of Behavior - 102. Cognition: human learning and memory |
Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 128. Degenerative disease: Alzheimer's-cognitive function |
Session: |
559. Cognition: human learning and memory VIII Poster |
Presentation Time: | Tuesday, November 7, 2000 1:00 PM-2:00 PM |
Location: | Hall G-J |
Keywords: | AGING* [AGEING], IMAGING, ALZHEIMER, MEMORY* |
Mild cognitive impairment (MCI) is a term for non-demented individuals with memory complaints and deficits greater than age-adjusted normal performance. Functional MRI (fMRI)may be a more sensitive method than other techniques to reveal functional abnormalities in individuals with MCI, only a proportion of whom progress to Alzheimer’s disease (AD). fMRI images were acquired using single shot spiral imaging. Subjects performed incidental encoding and retrieval tasks for coloured and black & white photographs contrasted to baseline fixation. During encoding subjects were required to make a semantic decision (natural vs. man-made) or a perceptual decision (colour vs. black & white). During retrieval, subjects judged whether they had seen the photographs in the previous encoding conditions. Initial analysis of young healthy adults (n=6) revealed activation in a network of regions in the memory tasks when contrasted to baseline fixation. Semantic encoding engaged a network of regions (fusiform gyrus, parietal, dorsolateral prefrontal cortex) more on the left than perceptual encoding which engaged more on the right. Right parahippocampal activation occured during retrieval(perceptual > semantic) in addition to the fusiform gyrus and parietal region. FMRI scanning is in progress in MCI, mild AD and normal elderly participants. This preliminary work, probing differential levels of memory processing, should indicate whether fMRI has potential as a cognitive stress test to distinguish individuals with MCI from normal aging.
Supported by MRC MT-13129
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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