Neuroscience 2001 Abstract
| Presentation Number: | 573.9 |
|---|---|
| Abstract Title: | SITES AND MECHANISMS OF PERIPHERAL CHEMOSENSITIVITY AFTER CAROTID (CBD) AND/OR AORTIC DENERVATION IN PIGLETS. |
| Authors: |
Brozoski, D. T.*1
; Serra, A.1
; Franciosi, R. A.1
; Forster, H. V.1,2
1Physiology, Medical College of Wisconsin, Milwaukee, WI 2Physiology, Zablocki VA Medical Center, MIlwaukee, WI |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Autonomic -- Respiratory regulation |
| Secondary Theme and Topics | Development<br />- Development of Sensory, Motor and Limbic Systems<br />-- Other sensory systems |
| Session: |
573. Autonomic: respiratory regulation--chemoreception Slide |
| Presentation Time: | Tuesday, November 13, 2001 3:00 PM-3:15 PM |
| Location: | Room 5B |
| Keywords: | AORTIC CHEMORECEPTOR, SEROTONIN, CONTROL OF BREATHING |
Ventilatory (VE) responses to NaCN injections in the descending aorta of CBD piglets demonstrate plasticity in peripheral chemosensitivity (J.Appl.Physiol. 87:2128-2135, 1999). Further, immunostaining shows an increase in serotonin (5-HT) in the subendothelial and adventitia layers of the same aortic areas after CBD (FASEB J. 15(4):A422, 2001). The present study assesses whether the peripheral chemosensitivity after CBD in the aorta requires 5-HT and if chemosensitivity remains after combined aortic and carotid body denervation (AOD+CBD). In 25 piglets, peripheral chemosensitivity (VE responses) was assessed 3 weeks after carotid and/or aortic, or sham denervation by injections of 6.3 mM NaCN (0.05mg.kg-1) into the jugular vein, common carotid arteries and descending aorta, before (control) and after the IV administration of the 5-HT blockers, metoclopramide (MCP), and methiothepin (MTN). Venous NaCN VE responses did not differ among all groups (p = 0.531) whereas carotid responses were present in SHAM and AOD, but not in CBD or AOD+CBD piglets (p < 0.001). Aortic VE responses were present solely in the CBD group (p = 0.004). Cardiac NaCN injections in the AOD+CBD group also increased VE. MCP did not significantly alter the NaCN VE response in any group, but MTN abolished the aortic response in the CBD group (p = 0.035). These data suggest that 5-HT is involved in aortic chemosensitivity in CBD piglets, and that cardiac chemoreceptors contribute to peripheral chemosensitivity after AOD+CBD.
Supported by SIDS Research Fund of WI, AHA 9910088Z, NIH 25738 and Veterans Administration.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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