Neuroscience 2002 Abstract
| Presentation Number: | 578.14 |
|---|---|
| Abstract Title: | Real-time Functional Magnetic Resonance Imaging of Amygdala-Hippocampus Activation during Self-Induced Sadness. |
| Authors: |
Posse, S.*1
; Fitzgerald, D.1
; Habel, U.2
; Rosenberg, D.1
; Moore, G. J.1
; Schneider, F.2
1Dept Psychiatry & Behav Neurosci, Wayne State Univ, Detroit, MI 2Psychiatry and Psychotherapie, University of Duesseldorf, Duesseldorf, Germany |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Brain Metabolism, Transport and Blood Flow |
| Session: |
578. Brain metabolism, transport and blood flow I Poster |
| Presentation Time: | Tuesday, November 5, 2002 2:00 PM-3:00 PM |
| Location: | Hall A2-B3 O-14 |
| Keywords: | FMRI, LIMBIC SYSTEM, HUMAN, FEEDBACK |
A new real-time multi-echo fMRI technique with gradient compensation of susceptibility related signal losses was used to measure activation in amygdala and hippocampus during 60 s trials of self-induced sadness. 9 healthy adults (3 males, 6 females, 22-45 years) performed a validated mood induction paradigm with sad and neutral faces in repeated scans (10 trials each, total trials: 235). This technique enabled online comparison with self-rating of sadness in single trials and immediate feedback of amygdala-hippocampus activation to the subject to reinforce mood induction. Activation of predominantly left amygdala-hippocampus during sad mood induction was observed in all subjects and in 77 % of single trials. This activation does not appear to diminish with repeated mood induction. The linear correlation between the intensity of amygdala-hippocampus activation and self-rating increased with repeated scanning, possibly reflecting adaptation to the mood induction procedure. These results suggest that amygdala-hippocampus activation as measured by fMRI may be closely associated with feelings of self-generated sadness.
Fig.: Single trial sad mood induction.
Fig.: Single trial sad mood induction.
Supported by Joe F. Young Psych. Res. Train. Prog., NIDA, NIMH, DFG (Schn)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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