Neuroscience 2001 Abstract
| Presentation Number: | 550.15 |
|---|---|
| Abstract Title: | An MRI investigation of age-related structural changes in the rhesus monkey brain. |
| Authors: |
Wisco, J. J.*1
; Guttmann, C. R. G.2
; Warfield, S. K.2
; Wells III, W. M.2
; Killiany, R. J.1,2
; Rosene, D. L.1
; Moss, M. B.1
1Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 2Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Aging -- Other |
| Session: |
550. Aging: other--humans and other primates Poster |
| Presentation Time: | Tuesday, November 13, 2001 10:00 AM-11:00 AM |
| Location: | Exhibit Hall YY-31 |
| Keywords: | AGING, MONKEY, MRI |
We used MRI to investigate the effect of normal aging on the volume of selected brain structures in seven young (5-10 yrs.), five middle-aged (11-20 yrs.) and eight old (21-30 yrs.) monkeys (macacca mulatta). A 1.5T Signa GE scanner acquired coronal proton density- and T2-weighted images using two interleaved dual-echo spin-echo sequences [TR=3000ms; TE=30/80ms; 2.7mm slc, FOV=150mm (256 x 256), 1 nex]. The images were filtered to improve signal-to-noise, then the intra-cranial cavity (ICC) was segmented under visual guidance. Voxels within the ICC were classified and grouped into 11 structures of interest using automated statistical Expectation-Maximization (EM), and Spatially Varying Classification (SVC) segmentation algorithms adapted for monkey MRI analysis. One-way ANOVA revealed an overall significant effect of age group on the volume of forebrain white matter [F(2,17)=4.53, p=0.03]. A posteriori comparisons showed a significant reduction of forebrain white matter volume in the old-aged monkeys when compared to either the young or middle-aged monkeys, but no statistical difference was detected between the young and middle-aged monkeys. In addition, no changes were seen in any of the other anatomical structures analyzed, including forebrain gray matter. These results suggest that the specific age-related reduction in forebrain white matter can be detected in vivo, and that this loss reaches the level of significance sometime between middle- and old-age.
Supported by NIH grants P01 AG00001; F31 AG05897; P41 RR13218-01; R01 NS35142; R37 AG17609
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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