Neuroscience 2000 Abstract
| Presentation Number: | 540.16 |
|---|---|
| Abstract Title: | An impaired hyperglycemic response to repeated glucoprivation is not a sufficient stimulus for anestrus. |
| Authors: |
Zhou, D.*1
; Blum, R. M.1
; Schneider, J. E.1
1Biol Sci, Lehigh Univ, Bethlehem, PA |
| Primary Theme and Topics |
E. Endocrine and Autonomic Regulation - 62. Hypothalamic-pituitary-gonadal regulation |
| Session: |
540. HPG regulation II Poster |
| Presentation Time: | Tuesday, November 7, 2000 4:00 PM-5:00 PM |
| Location: | Hall G-J |
| Keywords: | Syrian hamster, estrous cycle, 2-deoxy-d-glucose, reproduction |
Glucoprivation triggers a sympathoadrenal response that results in hyperglycemia. In rats, repeated bouts of glucoprivation result in an impaired hyperglycemic response (Ritter, SFN Abstract p. 614,1999). It is possible that the factors that impair the hyperglycemic response also inhibit reproduction. In Syrian hamsters, systemic treatment with 2-deoxy-D-glucose (2DG) (1750 mg/kg) every 6 h on days 1 and 2 of the estrous cycle induced anestrus and impaired the hyperglycemic response to glucoprivation. Plasma glucose concentrations [Pglu] were significantly increased compared to saline-treated controls in 2DG-treated hamsters after the first (166±12.75 mg/dl), but not after the fifth 2DG injection (117±8.32 mg/dl). 5-thio-D-glucose (5TG), the glucose analog preferred for central treatment, was administered to the fourth ventricle (ICV) by either acute infusion (300 μg/3μl) every 6 h on days 1 and 2, or via minipumps that delivered 1μl/h (100 μg/μl) on days 4, 1 and 2 of the estrous cycle. Similar to 2DG treatment, both 5TG treatments caused increased [Pglu] at 3 h (241±17.52 mg/dl), but not at 27 h (110±3.57 mg/dl) after the start of administration. Although fourth ventricular 5TG treatment was associated with an initially robust hyperglycemic response and a later impairment of the hyperglycemic response to glucoprivation, anestrus was not induced by this treatment. Thus, treatments that cause impairment of the hyperglycemic response to glucoprivation do not necessarily induce anestrus. Detectors of glucoprivation in the hindbrain appear to influence hyperglycemia, however, contrary to previous data, they do not appear to induce anestrus in Syrian hamsters.
Supported by IBN9723938,DK53402
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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