Neuroscience 2000 Abstract
| Presentation Number: | 54.9 |
|---|---|
| Abstract Title: | Correlation of Meynert cell intrinsic collaterals with ocular dominance columns in monkey primary visual cortex. |
| Authors: |
Li, H.*1
; Fukuda, M.1
; Tanifuji, M.1
; Rockland, K. S.2,3
1Integrative Neural Systems, RIKEN Brain Science Institute, Wako-shi, Japan 2Cortical Organization and Systematics, RIKEN Brain Science Institute, Wako-shi, Japan 3Neurology, The University of Iowa, Iowa, IA |
| Primary Theme and Topics |
F. Sensory Systems - 79. Visual cortex: striate |
| Session: |
54. Visual cortex: striate--functional organization II Poster |
| Presentation Time: | Sunday, November 5, 2000 8:00 AM-9:00 AM |
| Location: | Hall G-J |
| Keywords: | Axon collaterals, layer VI, intrinsic signal imaging, horizontal intrinsic connections |
Meynert cells are large pyramidal cells at the border between layers V and VI in primary visual cortex(V1). They project to several cortical and subcortical areas, and have been reported to have widespread intrinsic collaterals within VI (Rockland, SFN Abstr 1999). In order to understand further the functional architecture of V1, we are investigating the correlation of intrinsic collaterals of Meynert cells with ocular dominance columns(ODCs). ODCs were demonstrated by optical imaging of the intrinsic signals after visual stimulation in anesthetized monkey. Meynert cell collaterals were labeled by pressure-injected biotinylated dextran amine(BDA). BDA injection was made one week after the imaging experiment, placed in reference surface image of V1. One week after injection, animal was perfused and the tissue was processed for DAB histochemistry. In the analysis, segments of Meynert cell axons were traced from the injection site and/or its vicinity. Four segments were serially reconstructed from within the optically imaged field of ODCs. By aligning the ODC map and the reconstructed collaterals on the imaged surface, we were able to verify the large spread of the collaterals within V1 and to show in addition that single segments innervate both left- and right-eye ODCs. In contrast, pyramidal cells in the supragranular layers are reported to have intrinsic collaterals specific to right or left ODCs. Thus, there may be important differences in the functional architecture of Meynert cells, perhaps related to their role in motion perception.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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