Neuroscience 2004 Abstract
| Presentation Number: | 466.3 |
|---|---|
| Abstract Title: | Modulation of serotonin receptor subtype responsiveness following prolonged cannabinoid treatment. |
| Authors: |
Hill, M. N.*1
; Sun, J. C.1
; Gorzalka, B. B.1
1Psychology, Univ British Columbia, Vancouver, Canada |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Behavioral Pharmacology -- Monoamines and behavior |
| Secondary Theme and Topics | Synaptic Transmission and Excitability<br />- Neurotransmitters<br />-- Cannabinoids |
| Session: |
466. Monoamines I Poster |
| Presentation Time: | Monday, October 25, 2004 10:00 AM-11:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # GGG7 |
| Keywords: | SEROTONIN, CANNABINOIDS, HYPOTHERMIA, CORTICOSTERONE |
Despite significant overlap in the behavioral and physiological roles of the serotonergic and endocannabinoid systems, little is known about the influence each of these systems exerts on the other. This research examined how chronic treatment with the cannabinoid receptor (CB1) agonist HU-210 (7-hydroxy-delta6-tetrahydrocannabinol 1,1-dimethylheptyl) at a dose of 100ìg/kg for 12 days affected the behavioral and physiological responses to 5-HT1A, 2A/2C receptor stimulation. HU-210 induced a sensitization of the wet dog shake response to the 5-HT2A/2C receptor agonist DOI ((+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane; 1 mg/kg IP), and a trend to an increased hyperthermic response to this drug. DOI administration lead to an unanticipated 50% mortality rate in rats pretreated with HU-210 due to apparent symptoms of serotonin syndrome. DOI-induced back muscle contractions were significantly reduced in animals pretreated with HU-210, suggesting that 5-HT2A and 5-HT2C receptors may be differentially regulated following this treatment. Additionally, the hypothermic response elicited by a challenge with the 5-HT1A receptor agonist DPAT (8-hydroxy-2-(di-n-propylamino)tetralin; 0.3mg/kg IP) was significantly attenuated in HU-210 treated animals, at 30, 60 and 90 minutes post injection. These data imply that chronic cannabinoid treatment may upregulate 5-HT2A receptors while concurrently downregulating 5-HT1A and 5-HT2C receptors, a finding which may partailly explain the association between excessive cannabis consumption and affective disease.
Supported by MSFHR, NSERC
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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