Neuroscience 2001 Abstract
| Presentation Number: | 530.13 |
|---|---|
| Abstract Title: | A FUNCTIONAL MRI STUDY OF STIMULUS-RESPONSE COMPATIBILITY IN CHILDREN AND ADULTS. |
| Authors: |
Thomas, K. M.*1
; Franzen, P. L.2
; Casey, B. J.1
1Sackler Institute, Weill Med College Cornell Univ, New York, NY 2Psychology Department, University of Arizona, Tucson, AZ |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition and Behavior -- Learning and memory |
| Session: |
530. Human cognition and behavior: learning and memory VII Poster |
| Presentation Time: | Tuesday, November 13, 2001 8:00 AM-9:00 AM |
| Location: | Exhibit Hall TT-23 |
| Keywords: | Basal Ganglia, Neuroimaging, Learning, Development |
The current study examined the development of frontostriatal circuitry involved in overriding a competing or well learned behavioral set in favor of a novel response mapping. Imaging studies of motor response learning, such as serial reaction time tasks, have implicated the insula cortex and basal ganglia regions in the learning of novel response patterns. Given the delay in maturation of prefrontal cortex and the basal ganglia, we predicted a developmental difference in performance on tasks involving stimulus-response conflict, presumably related to the developmental delay in organization of this circuitry. Using functional MRI, we compared the brain activation elicited during well-learned and novel stimulus-response mappings. Nine right handed adults (mean age=24.5 years, 3 females) and nine right handed children (mean age=8.8 years, 4 females) were scanned while performing the stimulus-response compatibility task. Echo planar images (TR = 6000, TE = 40, 128 X 64) were acquired in twenty-six 5 mm contiguous coronal slice locations. The results based on analyses of variance with a contiguity threshold of 3 pixels and p < 0.05 showed that incompatible mappings relative to compatible mappings resulted in increased activity in the insula cortex, basal ganglia and thalamus in both children and adults. Adults showed more prefrontal activity during novel response mappings, while children showed more basal ganglia and hippocampal activity, presumably related to the delay in maturity of frontal cortical systems in children.
Supported by 1K01MH01297 grant to BJC
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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