Neuroscience 2001 Abstract
| Presentation Number: | 525.14 |
|---|---|
| Abstract Title: | CNS ACTIVATION DURING BLADDER FILLING USING FUNCTIONAL MAGNETIC RESONANCE IMAGING. |
| Authors: |
Pontari, M. A.*1
; Greenstein, J. I.1
; Ruggieri, M. R.1,2
; Braverman, A. S.1
; Lemieux, S. K.3
1Urology, Temple Univ. Sch. of Med., Philadelphia, PA 2Pharmacology, Temple Univ. Sch. of Med., Philadelphia, PA 3Radiology, West Virginia Univ., Morgantown, WV |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Brain Metabolism, Transport and Blood Flow |
| Session: |
525. Brain metabolism, transport and blood flow I Poster |
| Presentation Time: | Tuesday, November 13, 2001 9:00 AM-10:00 AM |
| Location: | Exhibit Hall SS-25 |
| Keywords: | BRAIN IMAGING, BLOOD FLOW, PONS, CINGULATE |
Positive emission tomography (PET) and single photon emission computed tomography (SPECT) imaging measure neuronal activation indirectly by mapping regional cerebral blood flow (rCBF) with a temporal resolution of 40-70s and a spatial resolution of 5x5x5 mm. Functional magnetic resonance imaging (fMRI) acquires images that are sensitive to both percent oxygenation of hemoglobin and rCBF, called blood oxygenation level dependent (BOLD) contrast. fMRI images, with typical spatial resolution of 2x2x5 mm and temporal resolution of 1-2s are superior to PET or SPECT for assessing responses in the brain to stimulation.
18 axial, fast-spin echo, T2-weighted anatomical scans of the entire brain were acquired. Then fMRI BOLD images (same 18 axial slices, 2x2x6 mm) of the brain were acquired during bladder filling with saline until the subject signaled a full bladder then the bladder was drained. This cycle was repeated 2-7 times in seven female and one male paid volunteers. During these cycles, fMRI brain images were acquired every 8 seconds (N=5 subjects) or every 3 seconds (N=2 subjects).
In all subjects, activity was noted in the right inferior frontal cortex, the anterior cingulate gyrus, and the pons, consistent with findings using PET and SPECT methods. However, the MRI-BOLD signal response in the activated areas was indicative of a single event lasting less than 1 second in all subjects.
This indicates that although these areas are involved in the sensation of bladder filling and draining, they are not activated for extended periods of time, but may act as areas of “on-off” switches in the brain.
18 axial, fast-spin echo, T2-weighted anatomical scans of the entire brain were acquired. Then fMRI BOLD images (same 18 axial slices, 2x2x6 mm) of the brain were acquired during bladder filling with saline until the subject signaled a full bladder then the bladder was drained. This cycle was repeated 2-7 times in seven female and one male paid volunteers. During these cycles, fMRI brain images were acquired every 8 seconds (N=5 subjects) or every 3 seconds (N=2 subjects).
In all subjects, activity was noted in the right inferior frontal cortex, the anterior cingulate gyrus, and the pons, consistent with findings using PET and SPECT methods. However, the MRI-BOLD signal response in the activated areas was indicative of a single event lasting less than 1 second in all subjects.
This indicates that although these areas are involved in the sensation of bladder filling and draining, they are not activated for extended periods of time, but may act as areas of “on-off” switches in the brain.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
