Neuroscience 2001 Abstract
| Presentation Number: | 516.8 |
|---|---|
| Abstract Title: | HUMAN CEREBELLAR CORTEX: MRI-BASED TOPOGRAPHIC AND VOLUMETRIC PARCELLATION. |
| Authors: |
Makris, N.*1
; Hodge, S. M.2
; Kennedy, D. N.1,2
; Worth, A. J.1
; Haselgrove, C.1
; Harris, G. J.2
; Caviness, V. S.1
; Schmahmann, J. D.1
1Neurology, Mass General Hospital, Boston, MA 2Radiology, Mass General Hospital, Boston, MA |
| Primary Theme and Topics |
Motor Systems - Cerebellum -- Cortex |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Developmental Disorders |
| Session: |
516. Cerebellum: anatomy Poster |
| Presentation Time: | Tuesday, November 13, 2001 11:00 AM-12:00 PM |
| Location: | Exhibit Hall II-8 |
| Keywords: | MORPHOMETRY, BRAIN IMAGING, STRUCTURE, NEUROANATOMY |
Precise characterization of cerebellar anatomic subdivisions is required for functional and structural imaging studies of the cerebellum. Volumetric changes during normal development and aging, or related to pathology, emphasize the relevance of morphometric cerebellar cortical analysis. In addition, localization of functional imaging activation in human cerebellar cortex is aided by precise mapping of function onto structural anatomy. We describe a parcellation system of the human cerebellar cortex based upon neuroanatomy which conserves the topographic uniqueness of the individual brain and allows volumetric measurements of specific parcellation units (PUs) of the cerebellar cortex using T1 MRI. METHODS: Based upon a set of fissures, we have defined a system for parcellation of the human cerebellar hemispheres and the vermis into well defined, closed areas or PUs. To this end, eleven fissures and two splines were required. To apply this method to T1-weighted anatomic MR images, cerebellar cortical exterior and gray-white matter borders were defined, fissures were traced using a cross-referential morphometric tool, and cerebellar subdivision was performed. The resulting cortical segmentation is then amenable for morphometric and localization functions. RESULTS: The entire cerebellar cortex was parcellated into 35 PUs for each hemicerebellum. Specifically, 24 PUs were delineated in each cerebellar hemisphere and 11 PUs in each hemivermis. This system can be applied to the analysis of routine MR images for both functional localization and morphometric purposes.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
