Neuroscience 2001 Abstract
| Presentation Number: | 515.20 |
|---|---|
| Abstract Title: | NEURONAL ACTIVITY IN THE BASAL GANGLIA SYSTEM DURING FREELY MOVING AND TREADMILL TASKS IN RATS, THE EFFECTS OF Delta-9-THC. |
| Authors: |
Shi, L. H.*1
; Chang, J. Y.1
; Luo, F.1
; Woodward, D. J.1
1Physiology and Pharmacology, Wake Forest Uni Sch Med, Winston-Salem, NC |
| Primary Theme and Topics |
Motor Systems - Basal Ganglia -- Physiology |
| Secondary Theme and Topics | Motor Systems<br />- Basal Ganglia<br />-- Transmitters and receptors |
| Session: |
515. Basal ganglia: physiology IV Poster |
| Presentation Time: | Tuesday, November 13, 2001 11:00 AM-12:00 PM |
| Location: | Exhibit Hall GG-10 |
| Keywords: | cannabinoids, striatum, globus pallidus, subthalamic nucleus |
To estimate the effects of Delta-9-THC on locomotion activities, we used multiple-channel, single unit recording technique to investigate the neuronal activity in the dorsal striatum, the globus pallidus, the subthalamic nucleus and the substantia nigra pars reticulata during freely moving and treadmill locomotion tasks in rats. Sixty-four stainless steel microwires were implanted in those brain areas and neuronal activity were recorded simultaneously with a 64 channel recording device. Six infrared beams were used to measure the locomotion activity in the open field condition. Delta-9-THC pre-treatment (0.05-2.0mg/kg, i.p.) caused a decrease in locomotion activity in a clear dose dependent manner. Delta-9-THC treatment resulted in significant inhibition in the neural activities across all four basal ganglia areas recorded in the freely moving conditions. A treadmill task was employed to test the actions of Delta-9-THC in different behavioral contexts. Each trial consists of 20 seconds walking followed by 10 to 30 seconds random resting period. As observed in the freely moving condition, Delta-9-THC treatment (2.0mg/kg, i.p.) induced inhibitory responses in all the basal ganglia areas recorded in both treadmill on and off periods. Furthermore, a significantly higher degree of inhibition was found during resting period in comparison with walking periods. The study demonstrates potent inhibitory effects of cannabinoids on locomotion. This action may be the result of distributed inhibitory effects observed in the basal ganglia system where THC receptors are in high density.
Supported by DA-10370 to JYC, DA-2338 and NS40628 to DJW
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
