Neuroscience 2004 Abstract
| Presentation Number: | 448.5 |
|---|---|
| Abstract Title: | Rage in the diabetic brain: An important pathophysiological mechanism with cerebral neurons, glia, and white matter? |
| Authors: |
Toth, C. C.*1
; Schmidt, A.2
; Tuor, U.1
; Kaur, J.1
; Brussee, V.1
; Yan, S.2
; Tsutsui, S.1
; Zochodne, D.1
1Clin. Neurosciences, Univ. of Calgary, Calgary, Canada 2NY, 3330 Hospital Dr. NW, T2N4N1, |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neurodegenerative Disorders -- Other |
| Session: |
448. Neurodegeneration Mechanisms II Poster |
| Presentation Time: | Monday, October 25, 2004 8:00 AM-9:00 AM |
| Location: | San Diego Convention Center - Hall A-H, Board # UU6 |
| Keywords: | diabetes, white matter, advanced glycosylation end products, RAGE |
While the effects of diabetes upon the brain are well known, the pathophysiology underlying these pathological and functional changes is not understood. Human diabetes is associated with cognitive decline, stroke, cerebral atrophy and white matter abnormalities (WMA). One potential mechanism is the deposition of advanced glycosylation end products (AGEs) and their interaction with receptors for AGEs (RAGE). We studied an in vivo model of streptozotocin-induced chronic long term (8-9) experimental diabetes in mice and littermate age- and sex-matched controls. Immunohistochemical expression of RAGE was detected over multiple cerebral cell types, including neurons, astrocytes, oligodendrocytes, and microglia, as well as over white matter pathways. RAGE expression was significantly greater over regions of identified magnetic resonance imaging (MRI) T2 multi-echo image abnormalities and within regions of myelination deficit. Quantitative real-time polymerase chain reaction detected a 160 fold elevations in the quantity of RAGE mRNA in the diabetic brain. RAGE may be an important mechanism in the development of abnormalities within the diabetic brain.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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