Neuroscience 2003 Abstract
| Presentation Number: | 428.2 |
|---|---|
| Abstract Title: | MRI-based morphometric analysis of human cerebellar cortex with estimate of reliability. |
| Authors: |
Kennedy, D. N.*1
; Schlerf, J. E.1
; Hodge, S. M.1
; Haselgrove, C.1
; Albaugh, M. D.1
; Dieterich, M. E.1
; Boriel, D. L.1
; Tulloch, S.1
; Howard, J. D.1
; Seidman, L. S.1
; Rauch, S. L.1
; Caviness, V. S.1
; Makris, N.1
1Neurol. and Psychiatry, Mass Gen. Hosp, Boston, MA |
| Primary Theme and Topics |
Techniques in Neuroscience - Data analysis, physiological methods, statistics |
| Session: |
428. Techniques: Imaging & Anatomy Poster |
| Presentation Time: | Monday, November 10, 2003 9:00 AM-10:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # VV47 |
| Keywords: |
Introduction: Parcellation of the cerebellar cortex allows for detailed functional and structural imaging studies of the cerebellum. Volumetric changes during normal development and aging, or related to pathology, emphasize the relevance of morphometric analysis of cerebellar cortex. Previously, we described a parcellation system of the human cerebellar cortex based upon neuroanatomy [1]. In the present study morphometric analysis was performed on five normal humans, as well as intra- and inter-rater reliability measurements.
Methods: The cerebellar cortex of five normal human subjects was parcellated using T1-weighted anatomic MR images. The method of parcellation applied here was based on our previous study, which delineated 20 parcellation units (PUs) in each cerebellar hemisphere and 12 PUs in each hemivermis [1]. Reliability measurements were performed on the resulting parcellations.
Results and Discussion: Volumetric analysis and trials for intra- and inter-rater reliability were performed in a blind fashion. For instance, the five MRI datasets were parcellated by the same rater repeatedly. The average pixel overlap for corresponding structures was >80%. (For reference, values >80% are considered extremely reliable.) The values ranged from 72 to 93%, with 70% regions having >80% overlap. Volumetric analysis of PUs in the cerebellar vermis and hemispheres in these five subjects corroborated results from a previous publication in one subject [1]. This system can be applied to the analysis of MR images for both functional localization and morphometric purposes.
References: [1] Makris N, Hodge SM, Haselgrove C, Kennedy DN, Dale A, Fischl B, Rosen BR, Harris G, Caviness VS Jr., Schmahmann JD. Human Cerebellum: Surface Assisted Cortical Parcellation and Volumetry with MRI. J Cog Neuro, 15:4, 1-16, 2003.
Methods: The cerebellar cortex of five normal human subjects was parcellated using T1-weighted anatomic MR images. The method of parcellation applied here was based on our previous study, which delineated 20 parcellation units (PUs) in each cerebellar hemisphere and 12 PUs in each hemivermis [1]. Reliability measurements were performed on the resulting parcellations.
Results and Discussion: Volumetric analysis and trials for intra- and inter-rater reliability were performed in a blind fashion. For instance, the five MRI datasets were parcellated by the same rater repeatedly. The average pixel overlap for corresponding structures was >80%. (For reference, values >80% are considered extremely reliable.) The values ranged from 72 to 93%, with 70% regions having >80% overlap. Volumetric analysis of PUs in the cerebellar vermis and hemispheres in these five subjects corroborated results from a previous publication in one subject [1]. This system can be applied to the analysis of MR images for both functional localization and morphometric purposes.
References: [1] Makris N, Hodge SM, Haselgrove C, Kennedy DN, Dale A, Fischl B, Rosen BR, Harris G, Caviness VS Jr., Schmahmann JD. Human Cerebellum: Surface Assisted Cortical Parcellation and Volumetry with MRI. J Cog Neuro, 15:4, 1-16, 2003.
Supported by ALSA,NARSAD
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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