Neuroscience 2005 Abstract
| Presentation Number: | 456.10 |
|---|---|
| Abstract Title: | 4.7 T MRI-based detection of the tip of an electrode in monkey cortex. |
| Authors: |
Matsui, T.*1
; Koyano, K. W.2
; Koyama, M.2
; Naya, Y.2
; Takeda, M.2
; Nakahara, K.2
; Miyashita, Y.1,2
1Physics, Univ. of Tokyo School of Sci., Tokyo, Japan 2Japan, Hongo 7-3-1, 113-0033, |
| Primary Theme and Topics |
Techniques in Neuroscience - Staining, Tracing, and Imaging Techniques |
| Secondary Theme and Topics | Techniques in Neuroscience<br />- Physiological Methods |
| Session: |
456. Imaging by MRI and PET II Poster |
| Presentation Time: | Monday, November 14, 2005 9:00 AM-10:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # VV86 |
| Keywords: | ELECTROPHYSIOLOGY, HIGH FIELD |
Previous studies have detected locations of electrode tips in cortices by combining anatomical information acquired with MRI and tip positional information acquired by other techniques such as radiography (Nahm et al, Exp. Brain Res., 1994) or sonography (Glimcher et al, J. Neurosci. Methods, 2001). In this study, we tested the detectability of electrode tips directly on anatomical MR images. We first conducted in vitro study to optimize MR scan conditions and examined the accuracy of the tip detection. As a phantom we used a glass insulated tungsten electrode and reference glass tubes that were sunk together in Copper Sulfate solution. To estimate the accuracy of tip detection, distances between the electrode and the reference glass tubes were measured and compared in two different ways; one using MRI and the other using an optical microscope. MR images were acquired with a 4.7 T MRI scanner (Biospec 47/40, Bruker, Ettlingen) using a Fast Spin Echo sequence (in-plane resolution=50-200 µm by side, TR=1000-6000 ms, TE=20-80 ms) that minimize magnetic field distortion effects. At an optimum condition, estimated differences between the distances measured with MRI and those measured with microscope were around one voxel of an MR image. Next, we examined the applicability of the method to an in vivo situation using monkeys. In each penetration, with the electrode fixed, we acquired MR images and made electrolytic lesions (5-10 µA, 10-30 sec). We then compared the positions of the tips on MR images with those of electrolytic lesions in histological sections.
Supported by a Grant-in-Aid for Specially Promoted Research from MEXT (14002005) to Y.M. and JSPS Research Fellowships for Young Scientists (1711962) to K. W. K.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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