Neuroscience 2000 Abstract
| Presentation Number: | 495.11 |
|---|---|
| Abstract Title: | Longitudinal MRI in attention-deficit/hyperactivity disorder: effects of prior stimulant treatment in cerebellum and total brain. |
| Authors: |
Castellanos, F. X.*1
; Giedd, J. N.1
; Walter, J. M.1
; Sharp, W.1
; Zijdenbos, A.2
; Paus, T.2
; Evans, A. C.2
; Rapoport, J. L.1
1Child Psychiatry Br., NIMH, Bethesda, MD 2Montreal Neurological Institute , McGill University, Montreal, Canada |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 147. Neuropsychiatric disorders: pharmacological agents |
| Secondary Theme and Topics | A. Development and Regeneration<br />- 24. Developmental disorders |
| Session: |
495. Neuropsychiatric disorders I Slide |
| Presentation Time: | Tuesday, November 7, 2000 3:30 PM-3:45 PM |
| Location: | Room 287 |
| Keywords: | methylphenidate, amphetamine, IMAGING, pediatric |
We observed smaller volumes in total cerebrum and cerebellar vermis in cross-sectional studies of boys with ADHD. In a longitudinal study (Giedd et al., 1999), we described developmentally related changes in normal brain anatomy. We now examine longitudinal changes in ADHD, to test the hypothesis that anatomic abnormalities reflect medication effects rather than being intrinsic to the disorder. Subjects: ADHD girls (n=33, mean age = 10.0 ± 2.5 y), ADHD boys (n=40, 11.4 ± 3.4 y), normal girls (n=29, 9.9 ± 3.0 y) and normal boys (n=46, 11.1 ± 3.6 y). 17 patients (9 girls) were medication naïve prior to first MRI scan. Methods: All scans were obtained on the same Signa 1.5 T imager at a mean interval of 3.5 y. 56 ADHD children were medicated prior to first scan and throughout. 17 previously unmedicated ADHD Ss were treated naturalistically with stimulants by their own physicians. Results: Although total cerebral & adjusted cerebellar volumes were smaller in ADHD (p<.05), change over time was equivalent in these severe ADHD children & controls. Conclusions: Although total brain and cerebellum are smaller in ADHD, longitudinal development follows the normal pattern regardless of severity or medication history. Thus, we do not support the hypothesis that anatomic deviance is the result of cognitive activity nor of prior treatment with stimulants.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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