Neuroscience 2005 Abstract
| Presentation Number: | 454.19 |
|---|---|
| Abstract Title: | Effects of hypertension and aging on the cerebrovascular system of the rhesus monkey: MRI-based perfusion findings. |
| Authors: |
Jonak, E. M.*1
; Killiany, R. J.1
; Prusty, S.1
; Rosene, D. L.1
; Moss, M. B.1
1Dept Anatomy & Neurobiol, Boston Sch Medicine, Boston, MA |
| Primary Theme and Topics |
Techniques in Neuroscience - Staining, Tracing, and Imaging Techniques |
| Session: |
454. Imaging by MRI and PET I Poster |
| Presentation Time: | Monday, November 14, 2005 10:00 AM-11:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # VV46 |
| Keywords: | blood-brain barrier, gadolinium, Virchow-Robbins space, hyperintensities |
Untreated hypertension causes many vascular abnormalities such as thickening of the tunica media and luminal dilation in a response to increased flow. Aging may lead to alterations in the blood-brain barrier (BBB) and changes in the white matter. The co-morbidity of hypertension with age complicates identification of their independent contribution to age-related changes in the cerebrovascular system. To isolate the roles of hypertension and age we developed a non-human primate model of hypertensive cerebrovascular disease in which the thoracic aorta is surgically coarcted to 2.5 mm to induce sustained hypertension (systolic 150-185 mmHg). Rhesus monkeys were divided into four groups, young (5-8 yrs) and middle aged (15-20 yrs) normotensive and young and middle aged hypertensive. Two years after entry into the study, T1 weighted serial MR images were acquired on each monkey prior to and following injection of Magnevist (gadopentate dimeglumine), a contrast agent that normally doesn’t cross the BBB. Images were analyzed using Jim 3 software. Hyperintensities were identified using particle analysis as being voxels with intensities above the white matter range. The same hyperintensity cutoff level was used for both the pre and post Magnevist images and subtracting the two generated a difference score. The effect of age, regardless of blood pressure level, revealed a medium sized effect (Cohen’s d value of 0.603), while the effect of hypertension regardless of age, produced a large effect (Cohen’s d value of .793). These findings confirm that both aging and hypertension have deleterious effects on the vascular system of the central nervous system. Data from this study would be consistent with both luminal changes to the blood vessels and disruptions of the BBB. Ongoing analyses on tissue from the monkeys in this study with 14C sucrose at the time of perfusion along with morphometric analyses of vessel luminal diameter and Virchow-Robbins spaces will help to isolate the source of this etiology. Supported by NIH grant R37-AG17609.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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