Neuroscience 2005 Abstract
| Presentation Number: | 454.6 |
|---|---|
| Abstract Title: | Testing an MRI correlate of dentate gyrus neurogenesis in humans. |
| Authors: |
Wu, W. E.*1
; Huddleston, D.1
; Pereira, A. C. G.1
; Scarmeas, N.1
; Small, S. A.1
1Columbia Univ., New York, NY |
| Primary Theme and Topics |
Techniques in Neuroscience - Staining, Tracing, and Imaging Techniques |
| Session: |
454. Imaging by MRI and PET I Poster |
| Presentation Time: | Monday, November 14, 2005 9:00 AM-10:00 AM |
| Location: | Washington Convention Center - Hall A-C, Board # VV46 |
| Keywords: | BRAIN IMAGING, STROKE |
Introduction: By coupling in vivo imaging with post-mortem analysis, we have previously identified an MRI correlate of dentate gyrus neurogenesis in mice. Specifically, we have relied on MRI to estimate cerebral blood volume (CBV) in the dentate gyrus and the CA1 subfields of the hippocampal formation. By adjusting dentate gyrus CBV to CA1 CBV, we were able to reliably predict the degree of cell proliferation in the dentate gyrus of mice exposed to neurogenesis manipulations. Here, we test for this MRI profile in humans with strokes, an established inducer of neurogenesis.
Methods: CBV was measured with MRI in the dentate gyrus and the CA1 subfield in subjects with strokes and cognitively-matched controls.
Results: Regression analysis showed that dentate gyrus CBV, adjusted for CA1 CBV, was significantly elevated in the stroke group. Secondary analysis showed that dentate gyrus CBV was significantly correlated with a functional measure of activities of daily living.
Discussion: The spatial profile of CBV in the hippocampal formation of stroke patients was identical to the CBV profile previously documented to predict neurogenesis in mice. We are currently testing other inducers of neurogenesis, such as exercise, to confirm that MRI measures of CBV can accurately predict dentate gyrus neurogenesis.
Methods: CBV was measured with MRI in the dentate gyrus and the CA1 subfield in subjects with strokes and cognitively-matched controls.
Results: Regression analysis showed that dentate gyrus CBV, adjusted for CA1 CBV, was significantly elevated in the stroke group. Secondary analysis showed that dentate gyrus CBV was significantly correlated with a functional measure of activities of daily living.
Discussion: The spatial profile of CBV in the hippocampal formation of stroke patients was identical to the CBV profile previously documented to predict neurogenesis in mice. We are currently testing other inducers of neurogenesis, such as exercise, to confirm that MRI measures of CBV can accurately predict dentate gyrus neurogenesis.
Supported by NIH grant AG025161, the McKnight Neuroscience of Brain Disorders Award, The James S. McDonnell Foundation
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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