Neuroscience 2000 Abstract
| Presentation Number: | 493.1 |
|---|---|
| Abstract Title: | Cerebral metabolic deficits in abstinent methamphetamine abusers. |
| Authors: |
London, E.*1
; Ling, W.2
; Rawson, R.2
; Woods, R.3
; Mandelkern, M.4
; Miotto, K.5
; Simon, S.5
; Berman, S.2,5
; Newton, T.2
; Matochik, J.1
; Mogy, J.5
; Hayrapetian, A.5
; Shinn, A.5
; Kurian, V.1
; Mazziotta, J.3
1NIDA Brain Imaging Ctr., Baltimore, MD 2Psychiatry, Neuropsychiat. Inst., UCLA, LA, CA 3Brain Mapping Ctr., Neuropsychiat. Inst., UCLA, LA, CA 4West LA VAMC, LA, CA 5Medication Develop. Res. Unit, Long Beach VAMC, Long Beach, CA |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 144. Drugs of abuse: amphetamines |
| Secondary Theme and Topics | H. Other Systems of the CNS<br />- 101. Brain metabolism and blood flow |
| Session: |
493. Drugs of abuse: amphetamines--general Slide |
| Presentation Time: | Tuesday, November 7, 2000 1:00 PM-1:15 PM |
| Location: | Conference Auditorium A |
| Keywords: | ADDICTION, GLUCOSE METABOLISM, AMPHETAMINE, DRUG ABUSE |
Methamphetamine (METH) abusers have cognitive deficits that may contribute to their addiction. We aim to identify abnormalities in brain function that underlie such disturbances. Participants were paid volunteers (21–50 y). Abusers reported heavy METH use and no other major drug use; controls engaged in no substantial illicit substance abuse (light marijuana and alcohol allowed in both groups). METH users abstained for 5–11 days. Absolute regional and global cerebral glucose metabolism (rCMRglc, CMRglc) were assayed with PET and the [F-18]fluorodeoxyglucose method during performance of an attentional task. METH users (n=5) had 9% lower CMRglc than controls (n=4). The differences in cerebellar vermis, caudate nucleus (n.) and putamen were of similar magnitude (about 9–9.75%), while the orbitofrontal gyrus (OFC) showed a slightly greater decrement (10.5%). Analysis of normalized data (n=5)indicated elevated rCMRglc in inferior parietal lobule and cuneus of METH subjects. Considering the absolute metabolic rates, it appears that the latter two brain regions were spared a hypometabolic effect. METH abusers had cognitive deficits; scores on tests of abstract thinking and manipulation of information correlated with CMRglc and rCMRglc in basal ganglia. Defective rCMRglc in OFC supports the view that a defect in executive functioning contributes to METH abuse and should be considered in developing behavioral interventions for the disorder.
Supported by NIH Grants 1 Y01 DA 50038-00 and 1-RR00865
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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