Neuroscience 2000 Abstract
| Presentation Number: | 490.5 |
|---|---|
| Abstract Title: | MRI diffusion tensor tracking of neuronal pathways in living humans: accuracy, precision, and results in the visual system. |
| Authors: |
Conturo, T. E.*1
; Lori, N. F.1
; Akbudak , E.1
; Snyder , A. Z.1
; Shimony , J. S.1
; Burton , H.1
; Price , J. L.1
; Raichle , M. E.1
1Neuroimaging Lab, Mallinckrodt Inst. of Radiol., Washington Univ. Sch. of Med., 4525 Scott Ave., St. Louis, MO |
| Primary Theme and Topics |
I. Neural Basis of Behavior - 106. Cognition: methods and models |
| Secondary Theme and Topics | F. Sensory Systems<br />- 78. Subcortical visual pathways |
| Session: |
490. Cognition: methods and models I Slide |
| Presentation Time: | Tuesday, November 7, 2000 2:00 PM-2:15 PM |
| Location: | Room 262 |
| Keywords: | Tract Tracing , Magnetic Resonance Imaging , Functional Mapping , Network Connection |
Purpose: We evaluated the accuracy and precision of diffusion tensor tracking (DTT) using simulations, and applied DTT to study visual pathways in living humans. Methods: For simulations, synthetic diffusion-tensor MRI (DT-MRI) images were computed for a curved pathway and fed into the DTT procedure (1) after adding noise. Errors between simulated and ideal tracks were computed under various conditions. Human DTT experiments were performed using custom single-shot echo-planar DT-MRI. Tracks were computed from a whole-brain array of seed points (1), and pathways were obtained using a selection procedure based on anatomical or functional MRI (1). We obtained trans-commissural and geniculocalcarine tracts (GCTs), ventral (occipital-temporal) pathways, and U-fibers. Results: Typical accuracy and precision was < 1mm from simulation, consistent with experimental results (Figure). The tracked GCT, including Meyer's loop, connected the lateral geniculate nucleus with striate cortex. The trans-commissural pathway connected occipital poles and passed medial to the GCT. The temporo-calcarine tract passed inferior to the GCT at the occipital pole and bifurcated into lateral and medial pathways to the temporal lobe. The medial pathways curved toward the amygdala compatible with known connections in monkeys (2). Subcortical U-fibers spanned between the occipital pole and lateral visual cortex. Conclusion: DTT accuracy and precision can be estimated, and DTT can track fine anatomical details of several component pathways of the living human visual system. 1. PNAS, 96 (1999), 10422; 2. J Comp Neurol 230 (1984), 465.
Supported by NS06833.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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